Paper 6: SC Systems Immunology, Colorectal Cancer Flashcards Preview

MICB 402 > Paper 6: SC Systems Immunology, Colorectal Cancer > Flashcards

Flashcards in Paper 6: SC Systems Immunology, Colorectal Cancer Deck (6)
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1
Q

CMS1 tumours (5)

A
  • infiltration of cytotoxic T cells, NK cells, and macrophages
  • highly immunogenic
  • have high mutation load
  • PDL1 blocking phagocytic cells
  • type of colorectal cancer
2
Q

CMS4 tumours (3)

A
  • infiltration of myeloid derived suppressor cells
  • marked by inflammation and colitis
  • type of colorectal cancer
3
Q

what changes were made to the colon, blood, spleen, and BM immune system in tumour-bearing mice

A
  • tumour-enriched monoyctes (pTEMs) not normally present emerged
  • emergence of immuno-suppresant cells and loss of cDCs, etc
4
Q

how were the populations of phagocytes altered in tumour-bearing mice

A
  • expansion of the Ly6C+ macrophages in tumour setting
5
Q

do tumours have an impact on the gene expression profile of circulating monocytes

A
  • the do have an impact and likely impact expression of transcription factor and immuno-suppressant genes
6
Q

what do pTEMs do (2)

A
  • turn off T cell activity during cancer
  • act as an immuno-suppressant