Paraneolastic

Question 1

AMPA- which disease?

Answer 1

breast lung thymoma

memory loss
confusion

Question 2

Hu

Answer 2

SCLC

short term memory
confusion

Question 3

CRMP5

Answer 3

SCLC
Thymoma

subacute dementia
Chorea
confusion

Question 4

VGKC

Answer 4

SCLC
THYMOMA

verbal and visual memory deficits

Question 5

Ma-2

Answer 5

Testicular germ cell

short term memory
ataxia
diplopia
hypokinesis

Question 6

NMDA

Answer 6

teratoma in half

seizures
hypoventilation
dyskinesias
autonomic instability

Question 7

Stiff person syndrome

Answer 7

breast
lung
thymoma

associated with anti-GAD
anti-ampiphysin

Question 8

Opsoclonus/myoclonus

Answer 8

breast
SCLC

associated with ANNA-2 and anti-Ri

Question 9

painful sensory neuropathy or sensory ataxia

Answer 9

SCLC

anti-Hu

ANNA-1

VGKC

Question 10

proper limbic encephalitis with personality change, psychosis, seizures, occular dyskinesias

Answer 10

NMDA- teratoma
VGKC-SCLC, thymoma

Hu

Question 11

Anti-Yo

Answer 11

Ovarian or breast

See cerebellar degeneration

Question 12

Paraneoplastic cerebellar degeneration

Answer 12

ataxia
dysarthria
vertigo

yo!

breast-->ANNA-1, anti-Yo, anti-Ma
Hodgkin Lymphoma
SCLC-->ANNA-1, CRMP5
Ovarian-->ANNA-1, anti-Yo
Testicular
Thymoma