parasites Flashcards
(28 cards)
MOA of chloroquine
inhibits heme polymerase
unique ADR of chloroquine
visual disturbance
unique ADR of quinine
cinchonism- tinnitus, vertigo, dafness, headache
blackwater fever- massive hemolysis, hemoglobinuria
reserved for severe, life threatening malaria due to its ability to cause heart arrhythmia
quinidine
drug of choice for malaria requiring parenteral therapy
artesunate
1st line agent for treatment and prophylaxis of chloroquine-resistant sp
malarone (atovaquone + proguanil)
What is coartem?
arthemether + lumefantrine
used PO after stabilized on IV artesenate
cardiac ADR coartem
QT prolongation
alternative agent for chloroquine-resistant prophylaxis
doxycycline
drug that can be given in once weekly doses for prophylaxis
mefloquine
ADR of mefloquine
neuropsych syndrome (depression, psychosis and seizure)- makes it 2nd line therapy
only drug that targets liver form
primaquine
primaquine causes hemolysis in pts with
G6PD
2 luminal agents for E. histolytica
paromomycin and iodoquinol
MOA of metronidazole
converted to toxic nitro radical in a process that is unique to anaerobic bacteria and parasites
pregnancy recommendations for metronidazole
CI in 1st trimester
cat B in 2/3
effect of metronidazole on warfarin
increases INR, due to presence of MTT
unique ADR of metronidazole
metallic taste
medication used for metronidazole-resistance
tinidazole
MOA of albendazole
inhibits microtubule formation and depletes glycogen stores
albendazole in pregnancy
CI
MOA of PAM
depolarizing NM blocking agents leading to paralysis
MOA of praziquantel
increases cell membrane permeability and eventual disintegration of parasite
special cautions when taking praziquantel
swallow tablets whole
avoid driving for 2 days
