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Endocrine > Parathyroid > Flashcards

Flashcards in Parathyroid Deck (12):
1

What are the causes of primary hyperparathyroidism?

Adenoma.
Carcinoma.
Hyperplasia.
Familial endocrine disorders:
> multiple endocrine neoplasia.
> Jaws syndrome.
> Hypocalcuric hypercalcaemia.

2

What does primary hyperparathyroidism lead to?

Increased PTH release > increased serum Ca2+

3

What causes secondary hyperparathyroidism?

Hypocalcaemia > increased PTH release > parathyroid gland hyperplasia.

4

What causes tertiary hyperparathyroidism?

Increased PTH due to prolonged secondary hyperparathyroidism > hypercalcaemia.

5

What are the causes of hypoparathyroidism?

Parathyroidectomy.
Radioactive iodine treatment.
Hypomagnaesaemia - inhibits PTH release.
Di George syndrome.
Pseudohypoparathyroidism.

6

What will blood investigations for hypoparathyroidism show?

Low Ca2+
Low PTH.
Elevated phosphate

7

What is pseudohypoparathyroidism?

PTH insensitivity.

8

What will blood investigations for pseudohypoparathyroidism show?

Low Ca2+
Elevated PTH.
Elevated phosphate.

9

What is albrights hereditary osteodystrophy?

Autosomal dominant disorder which causes pseudohypoparathyroidism with developmental defects.

10

What are the symptoms of albrights?

Short stature.
Short 4th metacarpal.
Obesity.
Soft tissue calcification.
Mental retardation.

11

What is Di George syndrome?

Deletion on chromosome 22 > malfunctioning parathyroid glands > decreased PTH.

12

How does hypomagnaesaemia cause hypoparathyroidism?

Inhibits PTH release.