Parkinson's disease

Question 1

Is an example of a..

Answer 1

Hypokinetic disorder

- imbalance between direct and indirect pathways

Question 2

is a loss of the

Answer 2

• nigro-striatal dopaminergic pathway

- DA producing neutrons of the pars recta (SNc)

Question 3

DA loss leads to …

Answer 3

• Leads to excessive inhibition of the thalamo-cortical pathway
• increased activity in the STN (from the cortex)

Question 4

symptoms include

Answer 4

• tremor (Resting)
• bradykinesia (slowing of movement)
• rigidity (resistance to passive movement)

Question 5

treatment strategies include

Answer 5

• L-DOPA in adjunct with carbidopa (to reduce peripheral effects of NAd)
• DA agonists (Bromocriptine, pramipexole)
• MAO inhibitors (selegiline)
• DA releasers (amantidine)
  no treatments for underlying degeneration
• Surgical inactivation of the STN via DBT