Parkinson's Disease (PD) Flashcards

(31 cards)

1
Q

What are some common difficulties in gait with patients who have Parkinson’s disease?

A
  • Reduced walking speed / Shuffling steps
  • Bradykinesia
  • Freezing
  • Festination
  • Difficulty turning
  • Reduced arm swing
  • Weakness
  • Sensory loss
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2
Q

What is the 2nd most common neurodegenerative disorder in the world?

A

Parkinson’s disease

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3
Q

Is Parkinson’s disease more common in men or women?

A

Men

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4
Q

What is Parkinson’s disease?

A

Complex & progressive disorder characterised by various motor and non-motor symptoms

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5
Q

What are some features of Parkinson’s disease?

A
  • Resting tremor
  • Rigidity
  • Postural instability
  • Bradykinesia
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6
Q

What part of the brain does Parkinson’s disease affect?

A

Basal Ganglia

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7
Q

What are the (3) different dopamine pathways?

A
  • Mesocortical
  • Nigrostriatal
  • Mesolimbic
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8
Q

What does the mesocortical dopaminergic pathway effect?

A

-Cognition
- Memory
- Attention
- Emotion
- Behaviour
- Learning

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9
Q

What does the nigrostriatal dopaminergic pathway effect?

A

Movement Control

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10
Q

What does the mesolimbic dopaminergic pathway effect?

A
  • Pleasure
  • Reward seeking behaviours
  • Addiction
  • Emotion
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11
Q

What are some of the main criteria to be diagnosed with Parkinson’s disease?

A
  • Bradykinesia
  • Stiffness
    (and/or)
  • Tremor
  • Balance & gait disorder
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12
Q

What are the (3) stages of Parkinson’s disease?

A
  • Preclinical: neurodegeneration presentbut asymptomatic
  • Prodromal Parkinson’s Disease:motor and non-motorsymptoms arepresent with clinical diagnosis
  • Clinical Parkinson’s Disease: dopamine-responsive with bradykinesia
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13
Q

How is gait affected in Parkinson’s Disease?

A
  • COG anterior
  • Short steplength
  • Flexed posture
  • Reduced arm swing
  • Hypokinetic
  • Festinating
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14
Q

How does bradykinesia present in Parkinson’s Disease?

A

Slowness of movement:suppression of movement in the cortex due toincrease inhibition

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15
Q

How does rigidity present in Parkinson’s Disease?

A

Stiffness: typicallylead-pipeor cogwheelin the presence of a tremor, due to depletion of dopamine

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16
Q

How does a tremor present in Parkinson’s Disease?

A

Primarily resting ‘pill rolling’

17
Q

How does postural instability present in Parkinson’s Disease?

A

Flexed posture

18
Q

What are some of the less recognised early presentations of Parkinson’s disease?

A
  • Handwriting
  • Loss ofsmell
  • Slow initiation
  • Freezing
  • Festination
  • Dyskinesia
  • Dystonia
19
Q

What are some non-motor features of Parkinson’s disease?

A
  • Neuropsychiatric symptoms: Depression, Anxiety
  • SleepDisorders:restless legs,insomnia
  • AutonomicSymptoms: bladder andbowel,excessive sweating, sexual dysfunction
  • Gastrointestinal:constipation
  • Dribbling (difficulty managing their saliva)
  • Sensory Disturbances: pain
  • Fatigue
  • Nutritional issues / weight loss
20
Q

What are (2) medical managements of Parkinson’s disease?

A
  • Levodopa (dopamine)
  • Deep brain stimulation surgery
21
Q

What are non-medical managements of Parkinson’s disease?

A

Team management is key
- Enable activity
- Enable participation
- Quality of life
- Symptom control

22
Q

What can we offer as physios for patients with Parkinson’s disease?

A
  • Self-management
  • Prevent inactivity
  • Prevent fear to move andfalling
  • Improve physical capacity
  • Reduce pain
  • Delay onset activity limitations
  • Functional ability: transfers, gait, manual activity
  • Maintain vital functions
  • Prevent pressure sores
  • Prevent contractures
  • Support carers
23
Q

What are some things to consider during a Parkinson’s disease assessment?

A
  • Drug history: timing of medication is vital
  • Expectations and goals
  • Carer support
  • Falls
  • Non-motor symptoms
24
Q

What are some elements of objective assessment to complete for patients with Parkinson’s disease?

A
  • Observation during functional activities: tremor, dyskinesia, bradykinesia, balance
  • Range of movement and activity/power: trunk, LL and UL.
  • When assessing tone feel for - Rigidity- axial rotation, LL, UL
  • Sensation and proprioception
  • Coordination
  • Balance: perturbation,reactions, visual input
  • Gait:freezing,dual tasking,outdoor/ uneven
  • Functional: on/off floor,rolling, ly-sit,running, cycling, R&G,car transfers
  • Confounding factors: processing speed, problem solving, pain, fatigue
  • Respiratory function and pain management if appropriate
25
What is the exercise framework for patients with Parkinson's disease?
- Progressive resistance strength training - Cardiovascular training - Specific training (e.g., Nordic walking/balance training)
26
How much exercise is recommended for patients with Parkinson's disease?
- 2.5 hrs of moderate to vigorous exercise a week - Progressive resistance exercise for 2 days a week - Specific prescribed exercise (dual tasking/flexibility) 2 days a week
27
Describe the pathophysiology of Parkinson's disease.
- Programmed destruction of >70%  of neurons resulting in depletion of the neurotransmitter dopamine in the substantia nigra - This leads to changes in the basal ganglia circuitry and the features of PD (e.g., more inhibition (stop) of the thalamus leads to depressed or slow movement) - Impacts limbic and cortical pathways: leading to apathy, memory problems, depression + sleep disorders
28
What are some examples of exclusion criteria for Parkinson's disease?
- History of repeated strokes with stepwise progression of parkinsonian features - History of repeated head injury - Strictly unilateral features after 3 years
29
What are positive criteria for Parkinson's disease?
Three or more required for diagnosis of definite Parkinson’s disease in combination with diagnosis: * Unilateral onset * Rest tremor present * Progressive disorder * Persistent asymmetry affecting side of onset most * Excellent response (70-100%) to levodopa * Severe levodopa-induced chorea * Levodopa response for 5 years or more * Clinical course of ten years or more
30
What will physios need to be able to manage when it comes to Parkinson's disease?
- Mechanical pain (Shoulder, lower back ) - Muscle weakness - Stiffness - Falls & Fractures - Balance - Reduced exercise tolerance - Social isolation - Reassurance - Functional practice - Pain (Neuropathic) - Pressure relief - Chest infections - Contractures - Support to family and carers - Advice (t/f, manual handling)
31
What are symptoms of Parkinson's disease caused by?
Decrease in dopamine neurotransmitter