Part 1

Question 1

% of patients who develop dependence syndrome on benzodiazepines after taking them for a year

Answer 1

40%

Question 2

How much heroine does a typical user consume a day?

Answer 2

0.25-2g

Question 3

Drug named ice

Answer 3

Strong and pure form of amphetamine

Question 4

ACUTE side effect of lsd

Answer 4

Bad trips

Question 5

Suboxone

Answer 5

Buprenorphine and nalaxone

Question 6

Flunitrazepam

Answer 6

Date rape, tasteless, short acting potent benzodiazepine

Question 7

Most commonly used opoid in the country

Answer 7

Heroine

Question 8

Cold turkey

Answer 8

Opiate withdrawal

Question 9

Opiate withdrawal

Answer 9

Begins 6-8 hours after last dose
Peaks in 2 days
Dysphoric mood, nausea or vomiting, muscle aches, lacrimation or rhinorrhoea, pupil dilation, goose flesh (piloerection), sweating, diarrhoea, yawning, insomnia
Withdrawal symptoms reach their peak after 32-72 hours

Question 10

When’s it the best time for a pregnant woman to start opoid detoxification

Answer 10

2nd trimester

Question 11

Common s/e of clonidine

Answer 11

Sedation

Question 12

What is the risk of seizures assoc. with bupropion

Answer 12

1 in 1000

Question 13

What type of hallucinations do you get in benzodiazepine withdrawal

Answer 13

Kinaesthetic

Question 14

This is partly a hallucinogenic and stimulant. It is a substituted amphetamine

Answer 14

MDMA

Question 15

Main s/e of varenicline

Answer 15

Nausea

Question 16

How may caffeine elevate mood?

Answer 16

Increasing noradrenaline

Question 17

What drug causes the following intoxication:
Marked anxiety and depression
Ideas of reference, fear of losing mind, perceptual changes, depersonalisation, derealisation, synesthesia
Pupil dilation, sweating, palpitations, blurring of vision

Answer 17

Pcp

Question 18

How many people with alcohol withdrawal develop delirium tremens

Answer 18

5%

Question 19

What is triad of wernickes encephalopathy and how often is it seem

Answer 19

Ataxia, confusion, opthalmoplegia

10%

Question 20

% of men and women who drink above weekly limits of alcohol

Answer 20

Men - 27%

Women - 15%

Question 21

What is lifetime risk of suicide in dependent drinkers

Answer 21

10-15%

Question 22

Minimum duration required to make diagnosis of alcohol dependence

Answer 22

12 monthes

Question 23

How often is cerebellar degeneration reported in chronic alcoholics

Answer 23

40%

Question 24

What is dose of acamprosate in people over 60kg

And for those less than 60kg

Answer 24

666mg tds

666mg morning, 333mg mid-day, 333mg evening

Question 25

When do symptoms of delirium tremens peak after last drink?

Answer 25

72-96 days

Question 26

Chlormethiazole - why is this not used in alcohol detox

Answer 26

High risk of respiratory depression

Question 27

What does acamprosate act on

Answer 27

Synthetic taurine analogue Acts on glutamate and gaba Gi disturbance is most common s/e

Question 28

Common s/e disulfiriam

Answer 28

Halitosis

Question 29

Patients with wernickes encephalopathy show gliosis and small haemorrhages in:

Answer 29

Mammillary bodies

Question 30

Drug choice in alcohol detoxification in patients with chronic respiratory disease

Answer 30

Oxazepam

Question 31

Type 1 alcoholism

Answer 31

Milieu-limited ( caused by environmental factors ie living with alcoholics) Seen in equally in men and women No family history of alcoholism Use generally starts above age of 25

Question 32

Safe limit of alcohol consumption in men and women

Answer 32

Men: 21 units Women: 14 units

Question 33

Opoid detox with buprenorphine inpatient should last

Answer 33

7-14 days

Question 34

Amphetamine withdrawal

Answer 34

Dysphoric mood, suicide ideas, fatigue, vivid unpleasant dreams, increased appetite, hypersomnia, psychomotor retardation

Question 35

Current prevalence of heroin use in the uk ?

Answer 35

1%