Part 1

Question 1

What are the components of Nucleotide

Answer 1

Phosphate group; Nitrogenous base; Sugar

Question 2

Which Drug cause Drug induced Lupus

Answer 2

Methyldopa, Sulfadrugs, Hydralazine, Isoniazid, Procainamide, Phenytoin, Etanercept

Question 3

Histones a rich in which amino acids

Answer 3

Lysine; Arginine

Question 4

What is the rate limiting enzyme in de novo purine synthesis

Answer 4

Glutamine-PRPP Amidotransferase

Question 5

Lack of which enzyme in purine breakdown can cause SCID

Answer 5

Adenosine Deaminase

Question 6

Azathioprine and 6-MP is metabolized by which enzyme

Answer 6

Xanthine Oxidase

Question 7

What is the genetic inheritance of Lesch Nyhan Syndrome

Answer 7

X-Linked recessive

Question 8

What is the rate limiting enzyme in pyrimidine synthesis

Answer 8

Carbamoyl Phosphate Synthetase II

Question 9

What is the treatment of Orotic Aciduria

Answer 9

Uridine

Question 10

Lactose is a combination of which 2 monosaccharide

Answer 10

Galactose; Glucose

Question 11

Sucrose is a combination of which 2 Monosaccharide

Answer 11

Fructose; Glucose

Question 12

Where in the body does Na+ dependent entry of glucose occur

Answer 12

Intestinal epithelium

Renal Tubules

Question 13

Where is the GLUT-1 Transporter Found

Answer 13

Brain and RBC

Question 14

Where is GLUT 4 transporter found?

Answer 14

Fat tissue; Skeletal Muscle

Question 15

What enzyme is responsible for the Rate Limiting step of glycolysis

Answer 15

PKF-1

Question 16

What are the inhibitors of PFK-1

Answer 16

ATP; Citrate

Question 17

What are the inducers of PFK-1

Answer 17

AMP Fructose 2,6 Bisphosphate

Question 18

What activates Pyruvate Kinase

Answer 18

Fructose 1,6 BP

Question 19

What inhibits Pyruvate Kinase

Answer 19

ATP; Alanine

Question 20

What is the form of Cholesterol in chylomicrons

Answer 20

Cholesteryl Ester

Question 21

Which cell type synthesizes Chylomicrons

Answer 21

Enterocytes

Question 22

What is packaged inside of the Chylomicrons

Answer 22

Triglycerides; Cholesterol Esters; Vitamins ADEK

Question 23

What enzyme is used in synthesize HMG-CoA

Answer 23

HMG-CoA Synthethase

Question 24

Which Enzyme in cholesterol synthesis is inhibited by statins

Answer 24

HMG-CoA Reductase

Question 25

The Liver secretes which lipoprotein(s) to deliver cholesterol and triglyceride to the body

Answer 25

VLDL; HDL

Question 26

What apoprotein are on HDL

Answer 26

A-I; C-II; Apo E

Question 27

Which enzyme(s) remove triglyceride from VLDL

Answer 27

Lipoprotein Lipase; CETP

Question 28

Which enzyme(s) remove(s) triglyceride from IDL

Answer 28

Hepatic lipase; CETP

Question 29

HDL is a repository for which apolipoproteins

Answer 29

APO C-II; Apo E

Question 30

What must be present for GKRP to inactivate Glukokinase

Answer 30

F6P

Question 31

What enzyme commits glucose to glycolysis

Answer 31

PFK-1

Question 32

Alanine inhibits which enzyme in glycolysis

Answer 32

Pyruvate Kinsae

Question 33

What cells are most effected by Pyruvate Kinase Deficiency

Answer 33

RBCs

Question 34

What is the intermediate in the conversion of pyruvate to PEP in glyconeogenesis

Answer 34

Oxaloacetate (OAA)

Question 35

What enzyme converts pyruvate to Oxaloacetate in Glyconeogenesis

Answer 35

Pyruvate Carboxylase

Question 36

What enzyme converts Oxaloacetate to PEP in gluconeogenesis

Answer 36

PEP Carboxykinase

Question 37

What cofactor(s) is(are) required by pyruvate carboxylase

Answer 37

ATP; Biotin; CO2

Question 38

What cofactor(s) are required by PEP carboxylase

Answer 38

GTP

Question 39

Biotin is a cofactor of which enzymes

Answer 39

Pyruvate FCarboxylase; Acetyl-CoA-Carboxylase; Propionyl-CoA Carboxylase

Question 40

What is the rate limiting step for gluconeogenesi

Answer 40

FBPase -1

Question 41

Where in the body is Glucose 6 Phosphate found

Answer 41

Liver and Kidney

Question 42

In what organelle is Glucose 6 Phosphatase active

Answer 42

Endoplasmic Reticulum