Part VI

Question 1

[column, eluent] Pb 201 -Tl 201

Answer 1

c: dilute/nitric acid/BIO REX 70
e: ammonium acetate solution

Question 2

[column, eluent] Sn 133- Ln 133

Answer 2

c: zirconium oxide
e. 0.05 NaNCL/HCL

Question 3

[column, eluent] Ge 68 - Ga 68

Answer 3

c: tin dioxide
e: HCl

Question 4

[column, eluent] Rb 81-K81

Answer 4

c: Bio Rad Ag/MP-50
e: humidified oxygen

Question 5

[column, eluent] Zn 62-Cu 62

Answer 5

c: DOWEX-NHCl
e: NaCl

Question 6

[column, eluent] Sr 82-Rb 82

Answer 6

c: CG Amberlite
e: glycine

Question 7

[column, eluent] Mo 99 -Tc99m

Answer 7

c: stannic oxide
e: NaCl/saline solution

Question 8

[ML] Pb 201 -Tl 201

Answer 8

active transport (Na+/K+ pump)

Question 9

[ML] Sn 133- Ln 133

Answer 9

simple diffusion

Question 10

[ML] Ge 68 - Ga 68

Answer 10

cellular migration and sequestration

Question 11

[ML] Rb 81-K81

Answer 11

simple diffusion

Question 12

[ML] Sr 82-Rb 82

Answer 12

active transport

Question 13

will happen when the ratio of activity of p and d nuclide reach a constant rate

p longer h than d

Answer 13

radioactive equilibrium

Question 14

when decay constant of p RN is lesser than d RN by a factor of 10-100 (will only happen if d RN have shorter h than p RN h)

Answer 14

transient equilibrium

Question 15

when the decay constant of p RN is much lesser by factor of 100 or more (will only happen if p has extremely longer h than d RN)

Answer 15

secular equilibrium

Question 16

Transient E. EXAMPLE

Answer 16

99Mo :66 hrs
99mTc :6hrs

Question 17

Secular E. EXAMPLE

Answer 17

68Ge: 270 d
68Ga: 68 min

Question 18

Routes of RP Administration

Answer 18

1. Intravenous
2. Oral
3. Nasogastric - infants
4. Subcutaneous - interdigital web space for lymphatics
5. Inhalation -better by mouth

Question 19

Types of Localization

Patty
Fatty
Fully
Moaning
After
Carl
Slid
Patato
Man
RePICh

Answer 19

1. Passive Diffusion (Simple Diffusion )
2. Filtration
3. Facilitated Diffusion
4. Metabolism
5. Active Transport
6. Compartmentalization
7. Cell Sequestration
8. Phagocytosis
9. Cell Migration (Chemotaxis)
10. Receptor Binding
11. Capillary Blockade
12. Ion Exchange
13. Chemisorption

Question 20

18F-FDG

Answer 20

Passive diffusion, Metabolism (Glycolytic Intermediate)

for epilepsy

Question 21

18F-DOPA

3,4-di hydroxyl-6-[18F] fluoro-phenylalanine

Answer 21

Metabolism (Catecholamine pathway)

for CNS disorders, schizophrenia, Parkinson’s

Question 22

68Ga-DOTA

Answer 22

Receptor binding (Somatostatin-peptide)

for neuroendocrine tumours

Question 23

68Ga-PSMA

prostate specific membrane antigen

Answer 23

Receptor Binding (Ag-Ab binding)

for prostate CA

Question 24

99mTc-MDP

Answer 24

Chemisorption

for bone scintigraphy

Question 25

99mTc-DTPA | diethylenetriaminepentaacetic acid

Answer 25

Filtration, Urinary tract compartment ## Footnote for renal imaging

Question 26

99mTc-DMSA | dimercaptosuccinic acid

Answer 26

Tubular reabsorption ## Footnote for renal scan

Question 27

99mTc-MIBI | methoxyisobutylisonitrile

Answer 27

Passive diffusion, electrostatic binding to mitochondria ## Footnote for eval patho w/in cardiac, br, parathyroid tissues

Question 28

99mTc-HIDA | hepatobillary iminodiacetic acid

Answer 28

Organic ion transport, like Bilirubin: Hepatobiliary compartment ## Footnote for eval hepatobilliary disorders

Question 29

99mTc-HMPAO | hexamethylphenylamineoxime

Answer 29

Diffusion through blood brain barrier (lipophilic) Metabolism( trapping by intracellular hydrolysis) ## Footnote for AD brain

Question 30

99mTc-ECD | ethyl cyysteinate dimer

Answer 30

Diffusion through blood brain barrier, Metabolism(enzymatic de esterification in the cell, non diffusible) ## Footnote for movem. disorders, dx dimentia

Question 31

Na99mTc04 | pertechnetate

Answer 31

Active transport ## Footnote for thyroid

Question 32

Na (131 I, 131 I, 124 I) | sodium iodide

Answer 32

Active transport, Metabolism (Organification) ## Footnote for hyperthyroidism and differentiated thyroid CA

Question 33

177 Lu DOTA

Answer 33

Receptor binding (Somatostatin-peptide) ## Footnote for thyroid CA

Question 34

177 Lu PSMA | prostate specifice membrane antigen

Answer 34

Receptor Binding (Ag-Ab binding) ## Footnote for metastatic prostate CA

Question 35

153Sm-EDTMP | ethylenediaminetetramethylenephosphonate

Answer 35

Chemisorption ## Footnote for bone CA