PASS PHARM DRILLS

Question 1

P450 Dependent Rx

Answer 1

W - Warfarin
E - Estrogen
P - Phenytoin
T - Theophylline 
D - Digoxin??

Question 2

P450 Inhibitor

Answer 2

“I’D SMACK QUIN”

I - INH
D - Dapsone
S - Sulfa Drugs
M -Macrolides
A - Amiodarone
C - Cimetidine
K - Ketoconazole
Q - Quinolones

*PLUS*
Sodium Valproate
Fluconazole
Alcohol (Binge)
Chloramphenicol
Ciprofloxacin
Omeprazole
Metronidazole
Grape Fruit Juice

Question 3

P450 Inducer

Answer 3

CRAP GPS Induce Madness

C - Carbemazepines
R - Rifampicin
A - Alcohol
P - Phenytoin 
G - Griseofulvin
P - Phenobarbitone
S - Sulphonylureas

PLUS
Barbituates
St. John’s Warts
Phenobarbital

Question 4

Atypical Bugs (4)

Answer 4

CLUM

C - Chlamydia
L - Legionella
U - Ureaplasma
M - Mycoplasma

Question 5

30s Subunit Inhibitor

Answer 5

Aminoglycosides
Tetracyclines

*Blocks translation

Question 6

50s Subunit Inhibitor

Answer 6

Chloramphenicol
Clindamycin
Erythromycin (Macrolides)
Lincomycin
Linezolid

Question 7

“Buy AT 30, CCELL at 50”

Answer 7

30
A - Aminoglycosides
T - Tetracyclines

50
C - Chloramphenicol
C - Clindamycin
E - Erythromycin (Macrolides)
L - Lincomycin
L - Linezolid

Question 8

Simple Gram Negative Bugs (3)

Answer 8

E. coli
Proteus
H. influenza

Question 9

Rifampin is given q.d.

Explain characteristic pattern.

Answer 9

Half Life --> Long
Fat Soluble
Uncharged
Small size
Base
Easy to Absorb
Give p.o.
High Vd
Enters skin --> Rash
Enters pancreas --> Pancreatitis
Enters muscles --> Myositis
CNS toxicity --> Confusion, Delerium
Liver Metabolism
Neprotoxic
P450
Caution in those w/ Renal Failure, Obesity

Question 10

Fat Soluble Rx, MC S/E

Answer 10

1. Hepatitis

2. Myositis

Question 11

Fanconi Syndrome Triad

Answer 11

1. Amino Acid –> Aminoaciduria
2. Glucose –> Glucosuria
3. Phosphaturia –> Phosphaturia

Question 12

Gray Baby Syndrome

Answer 12

Chloramphenicol

*Blocks Complex IV of ETC (Low Oxygenation)

Question 13

Rx for ALL anaerobes above diaphragm

Answer 13

Clindamycin

Question 14

MCC of Rx induced Pseudomembranous Colitis

Answer 14

Clindamycin

Question 15

Tx for Pseudomembranous colitis

Answer 15

Most effective –> Vancomycin

Current management –> Metronidazole x 2 before Vancomycin

Question 16

Urease Positive Bugs

Answer 16

BK Ppunchs

B - Brucelossis
K - Klebsiella 
P - Proteus
P - Pseudomonas
U - Ureaplasma
N - Nocardia
C - Cryptococcus
H - H. Pylori
S - S. Saprophyticus