passmed/pastest Flashcards

(41 cards)

1
Q

a prodromal phase of schizophrenia is associated with a poor/good prognosis

A

poor prognosis

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2
Q

factors associated with a poor prognosis in schizophrenia

A
strong family history 
gradual onset 
low IQ
premorbid history of social withdrawal 
lack of obvious precipitant
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3
Q

where in the body does lithium get concentrated?

A

bone and thyroid

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4
Q

what is the most commonly used prophylactic mood stabiliser used in bipolar disorder

A

lithium

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5
Q

adverse effects of lithium

A
nausea/vomiting, diarrhoea 
fine tremor 
nephrotoxicity 
nephrogenic DI
T wave flattening/inversion 
weight gain
idiopathic intracranial hypertension
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6
Q

how often should lithium levels be tested when started

A

weekly, and after each dose change until concentrations are stable

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7
Q

once lithium concentrations are stable, how often should lithium levels be checked

A

every 3 months

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8
Q

when should lithium levels be checked

A

12 hours post dose

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9
Q

how often should thyroid and renal function be checked in patients on lithium

A

every 6 months

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10
Q

which serious side effect is relatively common with clozapine?

A

agranulocytosis

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11
Q

what is passivity

A

the belief that your movements or sensations are controlled by an external force

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12
Q

what is avolition

A

a decrease in motivation to perform directed, purposeful activities

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13
Q

what is catatonia

A

a state of unresponsiveness that may include repetitive movements or abnormal postures

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14
Q

what is neologism

A

creation of new words

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15
Q

what type of hallucinations are most common in schizophrenia

A

3rd person auditory hallucinations discussing the patient or a running commentary on the patient’s behaviour

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16
Q

which antipsychotic most commonly causes galactorrhea

A

risperidone

also may occur with olanzapine or quetiapine

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17
Q

what are signs of somatisation disorder

A

multiple physical symptoms present for at least 2 years

patient refuses to accept reassurance or negative test results

18
Q

what are signs of hypochondriacal disorder

A

persistent belief in the presence of an underlying serious disease, eg cancer
patient refuses to accept reassurance or negative test results

19
Q

what are signs of conversion disorder

A

typically involves loss of motor or sensory function
the patient doesn’t consciously feign the symptoms (factitious disorder) or seek lateral gain (malingering)
patients may be indifferent to their apparent disorder

20
Q

what is dissociative disorder

A

dissociation is a process of ‘separating off’ certain memories from normal consciousness
in contrast to conversion disorder it involves psychiatric symptoms, eg amnesia, fugue, stupor
dissociative identity disorder is the new term for multiple personality disorder as is the most severe form of dissociative disorder

21
Q

what are signs of munchausen’s syndrome

A

also known as factitious disorder

the intentional production of physical or psychological symptoms

22
Q

what are sings of malingering

A

fraudulent simulation or exaggeration of symptoms with the intention of financial or other gain

23
Q

what are risk factors for suicide completion

A
sex (male)
age (young adult or elderly)
depression 
previous attempt (highest risk factor)
alcohol or drug use 
no spouse or other social support 
stated future intent
24
Q

what does a sore throat in a patient taking clozapine suggest and what should the investigation be

A

agranulocytosis

FBC

25
what is the underlying mechanism of tar dive dyskinesia
long term dopamine receptor blockade causing hypersensitive of dopamine receptors in the nigrostriatal pathway
26
what is a potential serious side effect of BDZs
respiratory depression | especially when prescribed with other respiratory depressant drugs eg opioids
27
symptoms of BDZ withdrawal syndrome
tremor anxiety perspiration seizures
28
which ions flow through GABA receptor-gated channels
chloride
29
how does GABA cause inhibitory effects
binds to GABA receptors, causing an influx of chloride ions and hyper polarisation, reducing the membrane potential
30
what is an obsession
an intrusive, unpleasant and unwanted thought
31
what is a compulsion
a senseless action taken to reduce the anxiety caused by an obsession
32
when is Eye Movement Desensitisation and Reprocessing (EMDR) therapy used
PTSD
33
what is Dialectical Behaviour Therapy (DBT) used for
borderline personality disorder
34
what is exposure-response prevention (ERP) therapy used for
OCD
35
protective factors of suicide completion
family support having children at home religious belief
36
mechanism of amitriptyline
inhibits monoamine reuptake on the presynaptic membrane
37
symptoms of SSRI discontinuation syndrome
``` increased mood change restlessness difficulty sleeping unsteadiness sweating GI symptoms (pain, cramping, diarrhoea, vomiting) paraesthesia ```
38
mechanism of action of haloperidol
block dopamine receptors
39
what is Korsakoff's syndrome
marked memory disorder often seen in alcoholics thiamine deficiency causes damage and haemorrhage to the mammillary bodies of the hypothalamus and the medial thalamus often follows on from untreated Wernicke's encephalopathy
40
features of Korsakoff's syndrome
anterograde amnesia (inability to acquire new memories) retrograde amnesia confabulation
41
features of wernicke's encephalopathy
nystagmus ophthalmoplegia ataxia