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MsK > Passmed Qs > Flashcards

Passmed Qs Flashcards

1
Q

SLE patients usually produce antibodies against …?

A

Doubke stranded DNA , ribonucleoprotein and histones

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2
Q

Characteristic finding of lupus nephritis

A

Proliferator wire loop glomerular histology in the presence of proteinuria and systemic symptoms of sle

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3
Q

Hydralazine can cause

A

Drug induced lupus

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4
Q

Difference between lupus and SLE

A

both present with : arthralgia, fatigue , malar rash

But SLE would be positive for anti dsDNA antibodies rather than anti - histone antibodies

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5
Q

Idiopathic membranous glomerulonephritis is related to what antibodies

A

Anti phospholipase A2 antibodies

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6
Q

Over 99% of patients with SLE are positive for what antibody

A

ANA- antinuclear antibodies

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7
Q

Where is cANCA commonly found

A

Granulomatosis with polyangitis

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8
Q

Where is Panca usually found

A

Eosiniphillic granulomatosis with polyangitis and microscopic polyangitis

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9
Q

What is the first radiological finding of AS

A

Sacroilitis

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10
Q

Which organism is most likely to cause osteomyelitis in kids with sickle cell

A

Salmonella

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11
Q

Ehlers danos is most commonly associated with a mutation in what type of collagen

A

Collagen type 3

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12
Q

Two common heart issues associated with patients who have ehlers danos

A

Mitral valve prolapse
Aortic regurgitation

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13
Q

narrow joint space, subchondral sclerosis , osteophytes indicates ?

A

osteoarthirtis

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14
Q

phalens test

A

flex wrist for 60 seconds = carpal tunnel syndrome

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15
Q

cauda equi na syndrome presents with

A

lassically presents with lower back pain, sciatica , reduced perianal sensation , late signs include urinary incontinence

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16
Q

hypocalcaemia can cause

A

face twitching

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17
Q

medication that can cause hypocalcaemia

A

desunumab

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18
Q

Low serum calcium, low serum phosphate, raised ALP and raised PTH indicates

A

osteomalacai

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19
Q

pseuudogout?

A

deposition of calcium pyrophosphate dihydrate crystals

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20
Q

what is olecranon bursitis

A

describes inflammation of the olecranon bursa, the fluid-filled sac overlying the olecranon process at the proximal end of the ulna.

This bursa exists to reduce friction between the posterior aspect of the elbow joint and the overlying soft tissues

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21
Q

plantar warts are caused by ?

A

HPV

22
Q

Boxer fracture commonly causes?

A

displacement of 5th metacarpal

23
Q

most common mechanism causing a scaphoid fracture

A

Falling onto an outstretched hand (FOOSH)

24
Q

reduction in red cells, platelets and white cells is known as ?

A

pancytopaenia

25
Q

chlorphenamine is what type of drug ?

A

H1 receptor agonist

26
Q

osteogenesis imperfecta occurs due to ?

A

abnormal type 1 collagen

27
Q

how do bisphosphonates treat osteoporosis

A

inhibit osteoclasts

Osteoclasts that resorb the bone take up the bisphosphonate and are unable to adhere to the bony surface to continue resorption.

28
Q

What is the most common anatomical location for bursitis to occur?

A

olecranon

29
Q

two common causes of osteomyelitis with patients who have sickle cell

A

salmonella- more common
s aureus

30
Q

histology for gout would show?

A

needle- shaped crystals with negative birefringence

31
Q

Why does felty syndrome present with

A

Triad of rheumatoid arthritis , neutropenia, splenomegaly

32
Q

list red flags for back pain

A
  • peri anal anasthesia
  • dm
    weight loss - cancer
  • high impact trauma
  • history of cancer
  • urinary incontinence
33
Q

felty syndrome?

A

RA + splenomegaly , neutropenia

34
Q

Caplans Syndrome

A

RA+ intrapulmonary nodules

35
Q

common SE of hydroxychloroquine

A

Nightmares and loss of visual acuity

36
Q

what spine joint does RA affect

A

atlanto axial joint c1-c2

37
Q

most common organism to cause reactive arthritis

A

chlamydia trachomatis

38
Q

where would gout most likely present

A

big toe

39
Q

what would gout show on aspiration

A

negative birefringement with needle shaped crystals

40
Q

what would pseudogout show on aspiration

A

positive birefringement with rhomboid crystals

41
Q

treatment for gout

A

1st line NSAID if no ckd or gi issues

IF CI then colchine

42
Q

se of colchine

A

diarrhoea
nv

43
Q

what meds can exacerbate gout

A

thiazide like diuretics

44
Q

risk factors for pseudogout

A

Advanced age

Injury or previous joint surgery

Hyperparathyroidism

Haemochromatosis

Hypomagnesaemia

Hypophosphataemia

45
Q

antibodies in sjogrens

A

Anti- ro
Anti - la

46
Q

antibodies in antiphospholipid

A

ANTI Phospholipid
lupus anticoagulant
anticardiolipin
anti beta 2 glycoprotein 1 antibodies

47
Q

complication of antiphispholipid

A

recurrent miscarriage

48
Q

ANTI JO 1 is most associated with

A

dermatomyositis

49
Q

A young patient with a history of active hepatitis B presents with systemic upset, nodular and ulcerating skin lesions and mononeuritis multiplex..,

A

polyarteris nodosa

50
Q

resp, renal and systemic features with positive PANCA is suggestive of ?

A

microscopic polyangitis

51
Q

canca +ve would indicate

A

granulomatosis with polyangitis

52
Q

what marker is used to monitor SLE

A

esr

MsK (14 decks)

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