Passmedicine Knowledge

Question 1

Diagnostic test for Sickle Cell

Answer 1

Haemoglobin electrophoresis

Question 2

How is tranexamic acid given

Answer 2

Iv bolus and slow infusion

Question 3

Features of Hyposplenism

Answer 3

Howell Jolly Bodies

Siderocytes

Question 4

Prophylaxis of Tumour Lysis Syndrome

Answer 4

Allopurinol

Question 5

1st line ix in peripheral arterial disease

Answer 5

Duplex ultrasound

Question 6

What is contained in cryoprecipitate?

Answer 6

Factor VIII

Question 7

How is acute chest crisis managed in Sickle Cell

Answer 7

Analgesia
Antibiotics
Oxygen
Fluids

Question 8

Tumour Lysis Syndrome Criteria

Answer 8

> Uric Acid
Potassium
Phosphate
< Calcium

And then one of the following

• Seuizure
• Arrythmia/Death
• Increased serum creatinine

Question 9

How to treat neutropenia and neutropenic sepsis in chemi

Answer 9

Neutropenia: Filgastrim

Neutropenic Sepsis: Piperacillin and Tazcobactam (Tazocin)

Question 10

What can be used to abet the effects of VWD befote surgery and how

Answer 10

Vasopressin analogues as it stimulates the release of VWf from weibel palade bodies in endothelial cells.

Question 11

What drugs are contraindicated in G6PD

Answer 11

Sulfa Drugs

Sulfonylureas (Gliclazide)
sulphonamides
Sulphasalazine

Primaquine
Ciprofloxacin

Question 12

What is the preferred NOAC for patients with renal impairment

Answer 12

Apixaban due to minimal renal clearance

Question 13

What is Richters Transformaton

Answer 13

CLL to NH Lymphoma

Question 14

Dabigatran Reversal

Answer 14

Idacruzimab

Question 15

Rovaroxaban and Apixaban Reversal

Answer 15

Adenexat Alfa

Question 16

Rivaroxaban and Pixaban mechanism

Answer 16

Factor Xa inhibitor

Question 17

Dabigatran Mechanism

Answer 17

Direct thrombin inhibitor

Question 18

Warfarin Mechanism

Answer 18

2, 7, 9 + 10 inhibitor

Question 19

Heparin mechanism

Answer 19

Activated Antithrombin III

Question 20

Heparin Reversal

Answer 20

Protamine Sulphate

Question 21

Warfarin Reversal

Answer 21

Vitamin K and PCC

Question 22

Pentad for TTP

Answer 22

Fever
Neuro Signs
Low platelets
Haemolytic Anaemia
Renal Failure

Question 23

Myelodysplasia transformation

Answer 23

AML

Question 24

Long term drug for sickle cell patients to prevent recurrence of crises

Answer 24

Hydroxycarbamide

Question 25

Mx of Polycythaemia

Answer 25

Aspirin to prevent thomrbotic events Venesection to keep HB in range Chemo in severe cases

Question 26

Typical blood picture after drinking alcohol

Answer 26

LOW platelets | macrocytic anaemia

Question 27

What are the platelet transfusion thresholds in active bleeding?

Answer 27

<30 for Clinically significant bleeding | <100 for severe bleeding or in critical sites

Question 28

Platelet targets pre invasive procedures

Answer 28

>50 50-75 for high risk bleeding sites >100 for surgery at a critical site

Question 29

Platelet transfusion threshold with no active bleeding

Answer 29

10

Question 30

Contraindications to platelet transfusion

Answer 30

Chronic bone marrow failure Autoimmune thrombocytopenia Heparin induced thrombocytopenia TTP

Question 31

Haemophillia A is a deficiency in what?

Answer 31

Factor VIII

Question 32

Sideroblastic anaemia picture

Answer 32

Microcyctic anaemia with normal iron studies and basophillic stippling of red blood cells.

Question 33

Polycythaemia transformation

Answer 33

Myelofibrosis or AML

Question 34

Chronic haemolysis causes which GI manifestation

Answer 34

Gallstones and subsequent billiary colic

Question 35

Whicih drug can precipitate renal failure in Myeloma patients

Answer 35

NSAIDS

Question 36

CML mamagement

Answer 36

Imatinib

Question 37

Acute haemoytic transfusion reactions are mediate by what

Answer 37

IgM

Question 38

Most common type of NHL

Answer 38

Diffuse large B cell lymphoma

Question 39

Biochemical pattern in myeloma without metastasis

Answer 39

Hypercalcaemia, normal Phosphate and ALP

Question 40

Low IgA predisposes to what

Answer 40

Anaphylaxis

Question 41

test for acute haemolytic transfusion reaction

Answer 41

Direct coombs test