Passmedicine/Pastest

Question 1

blue lines on gums

Answer 1

Burtons line - lead poisoning

Question 2

blood product most likely to cause a gram negative infection

Answer 2

platelets

Question 3

blood product most likely to cause a gram positive infection

Answer 3

red cells

Question 4

genetic change in burkitts lymphoma

Answer 4

c-myc

Question 5

diagnostic test for hereditary spherocytosis

Answer 5

osmotic fragility test

Question 6

mode of inheritance G6PD deficiency

Answer 6

x linked

Question 7

mode of inheritance of hereditary spherocytosis

Answer 7

autosomal dominant

Question 8

starry sky appearance on lymph node biopsy

Answer 8

burkitts lymphoma

Question 9

Hb threshold for transfusion

Answer 9

70g/L

Question 10

blood product given for the reversal of warfarin in severe bleeding e.g after RTA

Answer 10

prothrombin complex concentrate

Question 11

what is the most common hereditary thrombophilia

Answer 11

factor V leidan

Question 12

what is factor V leidan

Answer 12

activated protein C resistance

Question 13

transmission of which type of infection is most likely with platelets trasfusion

Answer 13

bacterial

Question 14

score for DVT

Answer 14

wells

Question 15

which type of hodgkins lymphoma has the worst prognosis

Answer 15

lymphocytic deplete

Question 16

mirror image nuclei

Answer 16

reedsternberg cells - hodgkins

Question 17

ecg changes after red cell transfusion

Answer 17

likely hyperkalaemia

Question 18

what symptoms indicate poor prognosis in lymphoma

Answer 18

b symptoms eg nigh sweats weight loss

Question 19

tear drop poikilocytes

leukoerythroblastic picture

Answer 19

myelofibrosis

Question 20

what can be given in VWF deficiency to reduce bleeding in surgery etc

Answer 20

desmopressin

Question 21

howell joly bodies

Answer 21

hyposplenism e.g. sickle cell disease

Question 22

what should always be prescribe if two or more units of blood are to be given

Answer 22

furosemide - as red cells can cause fluid overload

Question 23

hodgkiins lymphoma best prognosis

Answer 23

lymphocyte predominant

Question 24

what is the major constituent of cryoprecipiatate

Answer 24

factor VIII

Question 25

contraindication to platelet transfusion

Answer 25

TTP - treat with steroids instead

Question 26

platelet transfusion threshhold

Answer 26

10 x 10 (9) if not actively bleeding

Question 27

platelets in alcoholic liver disease

Answer 27

reduced

Question 28

crab features of myelome

Answer 28

C hypercalcaemia R raised ESR/renal failure A naemia B bence jones proteins/ bone pain/lytic lessions/fractures

Question 29

what can be given in active bleeding in someone with von willebrand

Answer 29

desmopressin as ADH stimulates VWF production

Question 30

smear cells

Answer 30

CLL

Question 31

what do spherocytes inicate

Answer 31

indicates extravascular haemolysis

Question 32

why are irradiated blood products used

Answer 32

to minimise risk of graft versus host as this is caused by reducing t lymphocytes in the blood product

Question 33

indications for irradiated products

Answer 33

Granulocyte transfusions Intra-uterine transfusions Neonates up to 28 days post expected date of delivery Bone marrow / stem cell transplants Immunocompromised (e.g. chemotherapy or congenital) Patients with/previous Hodgkins Disease

Question 34

indications for CMV free products

Answer 34

Granulocyte transfusions Intra-uterine transfusions Neonates up to 28 days post expected date of delivery Pregnancy: Elective transfusions during pregnancy (not during labour or delivery)

Question 35

what is post thrombotic syndrome

Answer 35

``` chronic venous hypertension painful, heavy calves pruritus swelling varicose veins venous ulceration ```

Question 36

treatmnet/prophylaxis of post thrombotic syndrome

Answer 36

compression stockings