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USMLE Step 1-2015 > pat > Flashcards

Flashcards in pat Deck (25):
1

BCR ABL
Gene product
Assoc tumor

Tyrosine kinase
CML, ALL

2

BCL-2
Gene product
Assoc tumor

Anti-apoptotic
Follicular and undifferentiated lymphoma

3

BRAF
Gene product
Assoc tumor

Serine-threonine kinase
Melanoma/non-Hodgkin lymphoma

4

c-kit
Gene product
Assoc tumor

Cytokine receptor
Gastrointestinal stromal tumor

5

c-myc
Gene product
Assoc tumor

transcription factor
Burkitt lymphoma

6

Her2/neu

tyrosine kinase
Breast. ovarian, gastric carcinomas

7

L-myc
gene prod
assoc tumor

trans factor
lung tumor

8

N-myc
gene prod
assoc tumor

trans factor
neuroblastoma

9

RAS
gene prod

GTPase
colon, lung, pancreatic cancer

10

RET
gene prod
assoc cancer

tyrosine kinase
men 2a/2b, medullary thyroid cancer

11

APC assoc tumor

Colorectal cancer

12

BRCA1/BRCA2
assoc tumor
gene product

breast and ovarian cancer
dna repair protein

13

DCC
assoc tumor
gene product

colon cancer
deleted in colon cancer

14

DPC4/SMAD4
assoc tumor
gene product

pancreatic cancer
deleted in pancreatic cancer

15

MEN1
assoc tumor
gene product

MEN 1
menin

16

NF1
assoc tumor
gene product

NF1
Ras GTPase activating protein (neurofibromin)

17

NF2
assoc tumor
gene product

NF2
merlin protein

18

p16
assoc tumor
gene product

melanoma
cyclin dependent kinase inhibitor 2A

19

p53
assoc tumor
gene product

human cancer, li fraumeni
transcription factor for p21 blocks G1-->s phase

20

PTEN
assoc tumor

breast cancer, prostate, endometrial

21

TSC 1

tumberous scloerosis
hamartin protein

22

TSC 2

Tuberous sclerosis
tuberin protein

23

VHL

VHL RCC
inhibits hypoxia inducible factor 1a

24

WT1/WT2

Wilms tumor (nephroblastoma)

25

CA 15-3/27-29

Breast cancer