path antibodies to learn

Question 1

Autoimmune hepatitis

Answer 1

Anti-smooth muscle antibody, Anti Liver Kidney microsomal-1 (anti-LKM-1). Anti-Soluble Liver Antigen (anti-SLA)

Question 2

Autoimmune haemolytic Anaemia

Answer 2

Anti-Rh Blood Group Antigen

Question 3

Autoimmune Thrombocytopenic Purpura

Answer 3

Anti-Glycoprotein IIb-IIIa or Ib-IX Antibody

Question 4

Bullous Pemphigoid

Answer 4

Anti-hemidesmosome

Question 5

Coeliac disease

Answer 5

Anti-tissue transglutaminase antibody (IgA), Anti-endomysial antibody (IgA)

Question 6

Congenital heart block in infants of mothers with SLE

Answer 6

Anti-Ro antibody

Question 7

Dermatitis herpetiformis

Answer 7

Anti-endomysial antibody (IgA)

Question 8

Goodpasture’s Syndrome

Answer 8

Anti-Glomerular basement membrane Antibody

Question 9

Graves’ Disease

Answer 9

Anti-TSH Receptor Antibody (stimulatory antibody)

Question 10

Hashimoto’s Thyroiditis

Answer 10

Antibodies to Thyroglobulin and Thyroperoxidase

Question 11

Myasthenia Gravis

Answer 11

Anti-Ach Receptor Antibody

Question 12

Pernicious anaemia

Answer 12

Antibody to gastric parietal cells (90%) and intrinsic factor (50%)

Question 13

Primary biliary cirrhosis

Answer 13

Anti-mitochondrial antibody

Question 14

Type 1 Diabetes Mellitus

Answer 14

Antibodies to Glutamate Decarboxylase and pancreatic β Cells

Question 15

Rheumatoid Arthritis

Answer 15

RF and Anti-CCP (more specific)

• Factors that increase amount of citrullinated peptide:
  o HLA- DR4
  o PADI (peptidlyarginine deaminase)
  o TPT-22 polymorphism
  o Smoking
  o Gingivitis

Question 16

SLE

Answer 16

Anti ds-DNA, anti-histone, anti-ribosome

Question 17

Sjogren’s

Answer 17

Anti-Ro and Anti-La
Destruction of exocrine glands

Question 18

Dermatomyositis

Answer 18

Anti-Jo1

Question 19

Polymyositis

Answer 19

Anti-Jo1

Question 20

CREST

Answer 20

Anti-Centromere

Question 21

Diffuse CREST

Answer 21

Anti-Scl70 (anti-topoisomerase)

Question 22

Granulomatosis with Polyangiitis
(Wegner’s)

Answer 22

cANCA- directed against proteinase 3

Question 23

Eosinophilic Granulomatosis with Polyangiitis (Churg Strauss)

Answer 23

pANCA- directed against myeloperoxidase

Question 24

Microscopic Polyangiitis

Answer 24

pANCA- directed against myeloperoxidase

Question 25

Psoriatic arthritis (HLA..)

Answer 25

HLA B27

Question 26

Ankylosing spondylitis (HLA..)

Answer 26

HLA B27

Question 27

Reactive Arthritis (HLA...)

Answer 27

HLA B27

Question 28

IBD (HLA...)

Answer 28

HLA B27

Question 29

HLA B27

Answer 29

PAIR Psoriatic arthritis Ankylosing spondylitis IBD Reactive Arthritis

Question 30

Goodpasture’s syndrome (HLA..)

Answer 30

HLA DR15/DR2

Question 31

Graves’ Disease (HLA...)

Answer 31

HLA- DR3

Question 32

Systemic Lupus Erythematosus (SLE) (HLA...)

Answer 32

HLA-DR3

Question 33

Type I diabetes hla?

Answer 33

HLA DR3/DR4

Question 34

Rheumatoid arthritis hla?

Answer 34

HLA-DR4 (4 walls in a rheum)

Question 35

Coeliac Disease hla?

Answer 35

DQ2/DQ8 (I ate (8) too (2) much)