Path Final Flashcards
(20 cards)
compare and contrast the histiocytic macrophage to the inflammatory macrophage
The histocytic macrophage is called a monocyte is is in the blood, when it enters the tissues it becomes a macrophage. If there is inflammation present they go to M1s if there is none then they become fixed tissue type macrophages.
Name three pore forming proteins that can have a significant role in inflammation
a
Name three major opsonins in inflammation
Fibronection, Complement, Ig’s
Name two free radicals that neutrophils use for killing ingested organisms
a
Name the two free radicals that macrophages use for killing ingested organisms
NO2- and OH- which is from NO
List at least four functions for IL-1
a
In order of longevity list three mediators that mediate vascular permeability in early inflammation
a
Etiologic agent for Mild locally extensive serious rhinitis
a
Etiology for Severe locally extensive fibrinous pleuropneumonia
a
Etiology for Acute multifocal necrotizing stomatitis
a
which factor is responsible for the initial very short lived mature neutrophilia seen in acute inflammation
a
what is the mediator responsible for the more prolonged neutrophilia in early inflammation
a
what mediator is responsible for maintaining a neutrophilia if inflammation is prolonged?
a
there are many, many mediators that can turn on inflammation but relatively few that turn it off name at least 4 ways inflammation can be turned off.
a
name an interleukin that is chemotactic for neutrophils and its source
IL-8 CXCL8, primary from macrophages also can be from endothelial and epithelial cells.
name an interleukin that is chemoattractive for eosinophils and its source
IL-5, It is produced by mast cells, Th2 lymphocytes and other eosinophils
what mediator does a macrophage need for full activation
a
distinguish a foreign body type granulomatous inflammatory lesion from a delayed typed hypersensitivity granulomatous inflammatory lesion. What mediators are involved in each
a
What special stains would youuseto identifythe following organisms or substances on histopathologyslides: Aspergillus fumigatus Cryptococcus neoformans Blastomyces dermatiditis Histoplasma capsulatum Toxoplasma gondii Mycobacterium tuberculosis Mycobacterium paratuberculosis Rhodococcus equi Nocardia asteroides
ds
How would you distinguish an enlarged, reactive lymphnode from an enlarged neoplastic lymphnode
s
