Path II test 2 Flashcards

1
Q

What are signs of pancoast tumor?

A

Tumor in the apex of the lung infiltrates brachial plexus.
Sx: pain numbness and weakness of affected arm (TOS)
Also may be involved with adjacent vertebrae and ribs

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2
Q

Horners syndrome

A
Tumor extension of pancoast tumor
Involves cervical and thoracic nerves
-ipsilateral miosis
-ptosis
-facial anhidrosis
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3
Q

Superior Vena Cava Syndrome

A
Tumor extension of pancoast tumor
Obstruction of venus drainage
-dilation of neck veins
-neck and facial edema
-redness
-
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4
Q

Potential complications of OM

A
Rupture TM
Mastoiditis
Infx to cochlea
Infxn to CNS and meninges
hearing loss
delayed/abnormal speech acquisition
Bullous myringitis
Cholesteatoma
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5
Q

Meniere’s disease:
Triad?

Causes?

Who?

A

“Endolympyhatic Hydrops”

  • Vertigo
  • Tinnitus
  • SNSL

Caused by pressure and volume changes in endolymph of vest. appararatus

Idiopathic

20-50 yo;

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6
Q

Acoustic Neuroma

A

Progressive Unilateral hearing loss
Benign tumor CN 8
Invasion/compression of internal auditory meatus, cerebellum. brain stem
-tinnitus, dizziness, otalgia, trigem neur, hemiparesis/paralysis of CN 7

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7
Q

What is Choleastoma/where is it

A

Epidermoid cyst lined with keratinizing squamous or columnar epithelium (mucous producing) and filled with amorphous debris and sometimes cholesterol

Arises in middle ear, tympanic membrane or adjacent struct., mastoid

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8
Q

What does progressive enlargement of choleastoma do?

What is sequlae?

A
Causes erosion into soft tissues and bones:
ossicles
 labyrinth,
 adjacent bone,
 surronging soft tissue

Sequlae:
grow into ossicle/labyrinth = deafness
Facial paralysis
Infection and intercranial abscess

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9
Q

How do you get choleastoma ?

A

cpngenital or acquired

Often from chronic OM
Maybe TM perforation or chronic retraction

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10
Q

What is otitis Externa?
How might it present?

Risks to get it?

A

“swimmers ear” infx external ear canal

  • local furuncle: S aureous
  • diffuse generalized infxn: bacterial

Risks:
Allergies, eczema, psoriasis seb. derm; decreased canal acidity, injury, chemical irritants

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11
Q

Malingnant Otitis Externa: what/where

who?

Appearance?

SSX

A

Osteomylitis of temporal bone
P. aueroginosa…often beginning with otitis externa

Elderly, diabetic, immunocompromised

Granulation tissue in external canal/jxn of bony margin of temporal bone with cartilage portion of pinna

Foul smelling, purulent otorrhea and severe otalgia

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12
Q

Scleritis vs conjunctivitis

A

scleritis vessels do not constrict with phenylephrine, vessels are not displaced by cotton swab.
More dangerous than conjunctivitis, can be from systemic dz like RA.
Not normally infection agent, unlike conjunctivitis
Maybe uvea infxn

Conjuntivitis
has rich distribution of lymphatic channels
May heal without incident
Maybe allergic, infectious, granulatomous

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13
Q

What is glaucoma

Optic nerve issues

A

collection of conditions leading to change in visual fiesld and optic cup

Elevated intraocular pressure
Lack of drainage of aqueous humor from ant. chamber

Optic nerve:
diffuse loss of ganglion cells
thinning of retinal nerve fiber layer
cupping and atrophy

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14
Q

Open angle glaucoma

A

Canals of schlemm/trabecular netwrks are open/accessible

resistance to aq. humor drainage in open angle: fluid pressure up

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15
Q

What glaucoma is more common and what causes it?

population?

what happens?

A

Primary…idiopathic…associated with MYOC gene sometimes.

eyes with shallow anterior: hyperopia

drainage blocked by narrow canal…iris bulges forward

Iris bombe/shadow/cresent shadow
lens epithelium maybe damaged: slit-lamp exam
corneal edema/bullous keratopathy

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16
Q

Secondary glaucoma

A

clogged trabecular network with open angle:

debris…various cells/proteins etc

Many types of closure:
neovascular: fibrovascular membrane…chronic retinal ischemia
ciliary body tumors…mechanical compression
necrotic tumors: neovascularization…retinoblastomas

Diabetic retinopathy, CRVO, ocular ischemia

17
Q

Preproliferative Diabetic retinopathy

What? Presentation? Risks?

A

Thickening of basement membrane of retinal BV
Common microaneurysms
Exudates result from hyperpermeable vasculature
Microocculsions of small vessels occur

Macular edema…vision loss
retinal detachment

18
Q

What is normal response to Acute blood loss?

A

Volume rapidly restored shifting h2o from intersitium
Hemo-dilution lowers hematocrit
lower Oxygenation of tissues = EPO from renal JGA cells
BM ups erythropoiesis
BM can increase production 7-8 fold

19
Q

Fe recycling Acute blood loss

Blood smear after loss?

A

Internal: can recycle from blood
External: Nope

Immediate: normocytic; normochromatic

Later: Lots of reticulocytes…larger; polychromatic

20
Q

Dog story

A

scientists bled out 30% of some dogs’ blood and replaced it with transfused blood, but the dogs all died. But then they repeated and transfused with saline, and the dogs lived. This is because the saline allows the fluid shift from the intra and intercellular spaces to return. Transfusing blood first made the dogs hyperosmotic which sucked out the remaining intercellular fluid.

21
Q

Why hemolytic anemia is dangerous

A

gallstones, pulmonary HTN, and jaundice, in addition to general anemia symptoms like SOB and fatigue.

22
Q

Coomb’s test

A

Direct Coomb’s test:
Warm AIHA, IgG ab chronic dz like SLE and RA

Indirect Coomb’s test:
Cold AIHA, IgM, acute, self limiting, acute dz like mycoplasma, mono, and viral