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Maddy - GI II Exam I - some pharm > Path - Oral Cavity and Salivary Glands > Flashcards

Path - Oral Cavity and Salivary Glands Flashcards

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1
Q

associated systemic dzs w/ periodontitis

A
  • AIDS
  • leukemia
  • Crohn’s
  • DM
  • Down’s
  • sarcoidosis
  • Chediak-Higashi syndrome
  • agranulocytosis
  • cyclic neutropenia
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2
Q

describe clinical presentation of recurrent herpetic gingivostomatitis

A

1-3 mm groups of vesicles on lips, nasal orifices, buccal mucosa, gingiva, and hard palate

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3
Q

demographic pyogenic granumola

A
  • children
  • young adults
  • pregnant women
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4
Q

salivary gland ductal obstruction due to stones

A

sialolithiasis

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5
Q

focal demineralization of enamel and dentin by acidic metabolites of fermented sugar produced by bacteria

A

dental carries

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6
Q

how are odontogenic keratocysts different from regular odontogenic cysts

A

ondoctogenic keratocysts are agressive

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7
Q

mucocele specifically of sublingual gland

A

ranula

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8
Q

mass on lower lip secondary to trauma

A

mucocele

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9
Q

painless, slow growing, mobile (if superficial) benign tumors within parotid or submandibluar areas or in buccal cavity

A

pleomorphic adenoma

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10
Q

complications of dental carries

A
  • weight loss
  • pain
  • life-threatening infections
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11
Q

most common fungal infection of oral cavity

A

c. albicans

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12
Q

sticky, colorless biofilm that collects b/w and on surface of teeth

A

dental plaques

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13
Q

small, poorly encapsulated, infiltrative, pink-gray lesions

A

adenoid cystic carcinoma

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14
Q

tumor in parotid and submandibular glands that grows along nerves (perineural)

A

adenoid cystic carcinoma

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15
Q

recurrent herpetic gingivostomatitis may persist in ____ patients

A

immunocompromised

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16
Q

HPV-associated and non-HPV-associated squamous cell carcinoma are found in what areas of the head and neck

A

HPV-associated: oropharynx

not HPV associated: oral cavity

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17
Q

TP53, P63, and NOTCH1 gene mutations

A

classic (tobacco) associated SCC

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18
Q

describe clinical presentation of acute herpetic gingivostomatitis

A

abrupt onset of diffuse oral vesicles w/ ulceration, lymphadenopathy, fever, anorexia, and irritability

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19
Q

clinical presentation of xerostomia

A
  • oral dryness
  • tongue fissuring
  • inflammatory salivary gland enlargement
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20
Q

benign mass made of up a mixture of ductal (epithelial) and myoepithelial cells

A

pleomorphic adenoma

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21
Q

mass due to ductal blockage or rupture with saliva leaking into surround stroma

A

mucocele

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22
Q

3 types of clinical presentation of c. albicans

A
  • pseudomembranous (thrush)
  • erythematous
  • hyperplastic
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23
Q

a carcinoma that arises from pleomorphic adenoma

A

carcinoma ex pleomorphic adenoma

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24
Q

complications of xerostomia

A
  • increased rate of dental caries
  • candidiasis
  • difficulty swallowing and speaking
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25
histology shows upper layer of columnar cells and lower layer with cuboidal to polygonal cells
warthin tumor
26
local and distal invasion sites of SCC
local: submandibular and cervical LNs distal: lungs, liver, bones
27
mechanisms of activation of herpes simplex virus
- UV light - URI - menstruation - immunosuppression - temperature extremes
28
prognosis of SCC for tobacco and HPV associated
5 year survival rate: - early stage tobacco-related: 80% - late stage tobacco-related: 20% - HPV: better prognosis
29
histology shows lots of mitochondria that look oncocytic
warthin tumor
30
common locations of odontogenic keratocysts
posterior mandible (jaw/jawbone)
31
acute pharyngitis and tonsillitis that causes gray-white exudative membrane, enlargement of LN in neck, palatal petechiae
infectious mono
32
white-coated tongue through which hyperemic papillae project
"strawberry tongue" from scarlet fever
33
fiery red tongue with prominent papillae
"raspberry tongue" from scarlet fever
34
P16 activation
HPV associated SCC
35
causes of xerostomia
- autoimmune inflammation and fibrosis (Sjogren) - radiation therapy - anticholinergics - nerve damage, stroke, tobacco, aging
36
slow growing, uncommon tumor in parotid and submandibular glands
adenoid cystic carcinoma
37
round to oval encapsulated mass 2-5cm in diameter arising in superficial parotid gland where it is readily palpable
warthin tumor
38
risk factors for squamous cell carcinoma of the oral cavity and oropharynx
- alcohol and tobacco use - actinic radiation - pipe smoking - betel quid nut and paan chewing - genetics
39
histology shows intercellular bridges in stratified squamous epithelium
SCC
40
inflammation of oral mucosa around teeth due to accumulation of dental plaque and calclulus
gingivitis
41
recurrent, painful superficial oral mucosal ulcerations of unknown etiology
aphthous ulcers (canker sores)
42
what syndromes can odontogenic keratocysts be associated with
Gorlin syndrome (nevoid basal cell carcinoma syndrome)
43
compare prognosis b/w HPV-associated and non-HPV-associated squamous cell carcinoma
better prognosis WITH HPV-association
44
most common primary malignant salivary tumor
mucopeidermoid carcinoma
45
inflammation of oral glands
sialadenitis
46
squamous cell carcinoma of the oral cavity and oropharynx is associated with what virus
HPV-16
47
unilateral, painful submandibular gland enlargement and purulent discharge following sialolithiasis (duct obstruction from stones) caused by bacteria
nonspecific bacterial sialadenitis
48
compare early and late stages of SCC in oral cavity
early: raised, firm, pearly, plaques or verrucous mucosal thickening late: ulcerations or protrusions with irregular indurated borders
49
superficial gray-white inflammatory membranes composed of fibrinosuppurative exudates
pseudomembranous oral candidiasis (thrush)
50
pt with predisposition to opportunistic oral infections including hairy leukoplakia
HIV
51
mixture of bacteria, salivary proteins, desquamated epithelial cells on teeth
dental plaques
52
most common type of inflammatory salivary gland lesion
mucocele
53
benign tumor occurring almost exclusively in the parotid gland
warthin tumor | papillary cystadenoma lympomatosum
54
epithelium lined cysts in the mandible and maxilla derived from odontogenic epithelium remnants
odontogenic cysts
55
location of most mucopeidermoid carcinomas
most commonly in parotid glands
56
small cells with dark, compact nuclei and scant cytoplasm, that are in tubular or cribriform patterns
adenoid cystic carcinoma
57
demographic for pts w/ oral candidiasis
- pts on broad spectrum antibiotics - DM - neutropenia - organ/bone marrow transplants - immunodeficiency
58
describe histological progression of oral SCC
hyperplasia --> mild/moderate dysplasia --> severe dysplasia/CIS --> SCC
59
SCC with preceding cancerous lesion
classic (tobacco) associated SCC | NOT HPV
60
red, velvety, eroded area of oral cavity
erythroplakia
61
most common form of viral dialadenitis
mumps
62
submucosal nodular mass of fibrous connective tissue stroma due to repetitive trauma
traumatic fibroma
63
dirty white, fibrinosuppurative, tough, inflammatory membrane over tonsils and retropharynx
diptheria
64
pale grey-white mass with no capsule and small mucin containing cysts
mucopeidermoid carcinoma
65
causes of sialadenitis
- autoimmune (sjogren's) - mumps - trauma (mucocele)
66
compare malignant transformation potential b/w leukoplakia and erythroplakia
erythroplakia has severe dysplasia with greater risk of malignant transformation
67
spotty enanthema in oral cavity, ulcerations in buccal mucosa, Koplik spots
measles
68
white patch or plaque of oral cavity that cannot be scraped off
leukoplakia
69
most common cause tooth loss <35
dental carries
70
where does classic (tobacco) associated SCC arise in the oral cavity
- ventral tongue - floor of mouth - lower lip - soft palate - gingiva
71
rapidly growing, highly vascular proliferation of granular tissue in giniva
pyogenic granuloma
72
describe clinical presentation of herpes labialis
1-3 mm lesions on lips
73
demographic for leukoplakia and erythroplakia
40-70 y/o, males, tobacco use
74
immunological disorders associated with aphthous ulcers (canker sores)
- sprue - celiac's - IBD - Behcet's
75
two main offenders for non-specific bacterial sialadenitis
s. aureus | strep. viridans
76
blue translucent mass on lower lip
mucocele
77
inflammation of supporting structures of teeth (periodontal ligaments), alveolar bone, cementum
periodontitis
78
MECT1-MAML2 fusion gene translocation
mucopeidermoid carcinoma
79
E6 and E7 expression leading to inactivation of p53 and RB
HPV associated SCC
80
cyst like space lined w/ inflammation granulation tissue devoid of epithelial lining
mucocele
81
compare warthin tumor and pleomorphic adenoma
both: benign, parotid gland warthin: much more often in males, cigarette smoking, 10% bilateral pleomorphic adenoma: ionizing radiation, PLAG1 overexpression
82
PLAG1 overexpression
pleomorphic adenoma
83
plummer-vinson syndrome (paterson-brown kelley syndrome) is associated with ______
esophageal WEBS

Maddy - GI II Exam I - some pharm (23 decks)

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