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Path- WBC Neoplasias Gomez Flashcards

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1
Q

proliferation centers

A

Small lymphocytic lymphoma

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2
Q

prolymphocyte

A

small lymphocytic lymphoma

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3
Q

smudge cells

A

chronic lymphocytic leukemia

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4
Q

peripheral T-cell lymphoma, unspecified

clinical features

A

mainly older adults; usually presents with lymphadenopathy; aggressive

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5
Q

T-cell neoplasm in children

A

anaplastic large-cell lymphoma

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6
Q

anaplastic large-cell lymphoma, genotype

A

ALK

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7
Q

anaplastic large-cell lymphoma, morphology finding

A

hallmark cells (horseshoe/kidney shaped)

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8
Q

ALK+ vs ALK-

A 
ALK+ = can be treated, better prognosis. usually seen in children. 
ALK- = cannot be easily treated, worse prognosis, usually seen in older pt's
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9
Q

adult t-cell leukemia/lymphoma, genotype

A

HTLV-1

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10
Q

adult t-cell leukemia/lymphoma, cell marker

A

CD25, CD4

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11
Q

adult t-cell leukemia/lymphoma, clinical features

A 
hypercalcemia 
cutaneous lesions 
marrow involvement 
pt's from Japan, West Africa, Caribbean 
aggressive
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12
Q

adult t-cell leukemia/lymphoma, morphology finding

A

cloverleaf nuclei

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13
Q

mycosis fungoides aka

A

Sézary syndrome

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14
Q

mycosis fungoides, clinical features

A

adults with cutaneous patches, plaques, nodules, or generalized erythema
indolent

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15
Q

Sezary syndrome

A

generalized exfoliative erythroderma

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16
Q

mycosis fungoides, morphologic finding

A

cerebriform nuclei

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17
Q

large granular lymphocytic leukemia, types

A

Cytotoxic T cell: indolent

NK cell: aggressive

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18
Q

large granular lymphocytic leukemia, associated syndrome

A

Felty syndrome

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19
Q

Felty syndrome

A

RA
splenomegaly
neutropenia

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20
Q

large granular lymphocytic leukemia, clinical features

A

adult pt with splenomegaly, neutropenia, anemia, sometimes accompanied by autoimmune disease

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21
Q

extranodal NK/T-cell lymphoma, genotype

A

EBV-associated

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22
Q

extranodal NK/T-cell lymphoma, cell marker

A

CD56

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23
Q

extranodal NK/T-cell lymphoma, clinical features

A 
Adults with destructive extra nodal masses, most commonly sinonasal
Aggressive. 
Midline lesions. 
Poor response to chemotherapy. 
Small vessel invasion.
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24
Q

MCC of acute leukemia associated with Down Syndrome

A

acute lymphoblastic leukemia

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25
lymphoblastic neoplasms, special stains
PAS/Myeloperoxidase
26
B-cell acute lymphoblastic leukemia/lymphoma, genotype
chromosomal translocations (hyperdploidy) t(12;21) involving RUNX1 and ETV6 t(9,22) BCR-ABL1
27
B-cell acute lymphoblastic leukemia/lymphoma, clinical features
predominantly children --> epistaxis and bleeding gums sx relating to marrow replacement and pancytopenia aggressive
28
B-cell acute lymphoblastic leukemia/lymphoma, cell markers
CD19, PAX5, sIg -, TdT +
29
B-cell acute lymphoblastic leukemia/lymphoma, prognosis
good for peds | bad for adults
30
T-cell acute lymphoblastic leukemia/lymphoma, genotype
chromosomal translocations | NOTCH1 in 70%
31
T-cell acute lymphoblastic leukemia/lymphoma, clinical features
predominantly adolescent males thymic mass variable bone marrow involvement aggressive
32
T-cell acute lymphoblastic leukemia/lymphoma, cell markers
CD1, 2, 5, 7, TdT+
33
Hodgkin lymphoma, most common subtype
nodular sclerosis
34
nodular sclerosis, morphologic finding
lacunar cells
35
nodular sclerosis, genotype
EBV+
36
nodular sclerosis, cell markers
PAX5, CD15, CD30
37
nodular sclerosis, epidemiology
young patients, M=F
38
most common form of Hodgkin lymphoma in patients >50y/o
mixed cellularity
39
mixed cellularity Hodgkin lymphoma, cell markers
CD15, PAX5, CD30
40
mixed cellularity Hodgkin lymphoma, genotype
EBV+
41
nodular sclerosis, clinical features
usually stage I or II disease frequent mediastinal involvement young pt
42
mixed cellularity, clinical features
>50% present as stage III or IV disease | M>F
43
Hodgkin Lymphomas, list subtypes
Classic - Nodular sclerosis - Mixed cellularity - Lymphocyte rich - Lymphocyte depletion Lymphocyte predominance
44
lymphocyte predominance Hodgkin lymphoma, morphologic finding
L&H (popcorn cell)
45
lymphocyte predominance Hodgkin lymphoma, cell markers
``` CD20+ CD15- CD30- EBV- BCL6+ ```
46
lymphocyte predominance Hodgkin lymphoma, clinical features
young males cervical or axillary lymphadenopathy mediastinal
47
Hodgkin lymphoma of developing countries and HIV-infected individuals
Lymphocyte depletion
48
Diagnostic morphologic finding of Hodgkin lymphomas
Reed sternburg cells
49
SLL/CLL genotype
Trisomy 13q = good prognosis | IGVH mutation = Zap70(-), CD38(-) = good prognosis
50
SLL/CLL clinical features
older pt bone marrow, lymph node, spleen, and liver disease indolent
51
follicular lymphoma, genotype
t(14;18) creating BCL2-IgH fusion gene
52
follicular lymphoma, cell of origin
centroblasts and centrocytes in the germinal center
53
follicular lymphoma, clinical features
older pt with generalized lymphadenopathy and marrow involvement indolent (MCC indolent lymphoma) low-grade splenic involvement
54
follicular lymphoma, cell markers
CD19, 20, 10, sIg, BCL6
55
diffuse large b-cell lymphoma, genotype
diverse chromosomal rearragements BCL6 BCL2 c-MYC
56
diffuse large b-cell lymphoma, clinical features
``` all ages, but most common in adults often appears as a rapidly growing mass 30% extranodal aggressive high-grade splenic involvement ```
57
diffuse large b-cell lymphoma, types
1. Mediastinal (young females, involving viscera and CNS) 2. Immunodeficiency (HIV pt's, etc) 3. Body cavity/Primary effusion (KSHV/HHV8 pt's with HIV)
58
Auer rods
acute myelogenous leukemia
59
acute promyelocytic leukemia, genotype
t(15;17) Retinoic acid receptor α (RARA) gene on chromosome 17 PML gene on chromosome 15 PML/RARA fusion proteins block differentiation at promyelocyte
60
CD34 - marker for...
multipotent stem cells
61
CD64 - marker for...
mature myeloid cells
62
CD33 - marker for...
immature myeloid cells
63
CD15 - marker for...
more mature myeloid cells
64
bevacizumab's antigen
VEGF
65
cetuximab's antigen
EGFR
66
rituximab's antigen
CD20
67
trastuzumab's antigen
HER2/neu
68
t(15;17)
APL, PML-RARA fusion gene
69
inv(16)
AML M4 | Myelocytic and monocytic differentiation; abnormal eosinophilic precursors in marrow with abnormal basophilic granules
70
APL treatment
all trans retinoic acid
71
Unique complication of APL
DIC
72
Most common myelocytic leukemia in Down Syndrome
acute megakaryoblastic leukemia
73
Pseudo-Pelger-Hüet cells
Myelodysplastic syndrome | Neutrophils with two nuclear lobes & abnormal granules
74
CML, most common translocation
BCR-ABL
75
Ringed sideroblasts
Myelodysplastic syndrome
76
polycythemia vera mutation
JAK2 V617F (in 95% of PV patients!)
77
treatment for CML
Imatinib
78
essential thrombocythemia mutation
JAK2
79
leukoerythroblastosis in blood smear is seen with...
primary myelofibrosis
80
primary myelofibrosis mutation
JAK2
81
dacryocytes
primary myelofibrosis
82
Langerhans cell Histiocytosis, morphologic finding
Birbeck granules
83
Langerhans cell histiocytosis AKA
eosinophilic granuloma
84
Hand-Schuller-Christian triad
calvarial bone defects diabetes insipidus exophthalmos

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