Path: WBC, Spleen, Thymus Flashcards Preview

COM - Heme/Lymph > Path: WBC, Spleen, Thymus > Flashcards

Flashcards in Path: WBC, Spleen, Thymus Deck (35)
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1
Q

EBV infection

A

Infects B-cells, but causes T-cell proliferation with follicular effacement

2
Q

t(12;21), CD10/19/20 in a child, GOOD prognosis

A

B-ALL

3
Q

t(9;22), CD10/19/20 in an adult, POOR prognosis

A

B-ALL

4
Q

PAS+, MPO-, TdT-

A

B or T-ALL

5
Q

CD19/20/23 + CD5

Clock Face Chromatin, smudge cells, splenomegaly, general LAD

A

CLL/SLL

6
Q

TRAP, BRAF, CD19/20, CD11c, incr. infection with Atypical Mycobacterium

A

Hairy Cell Leukemia

7
Q

t(14;18) –> BCL2

CD19/20/10/BCL6, CD5-

A

Follicular Lymphoma

8
Q

t(11;14) –> Cyclin D

CD5+, Painless LAD

A

Mantle Cell Lymphoma

9
Q

t(11;18) or t(1;14) –> BCL10, MALT1

A

Marginal Zone Lymphoma

10
Q

t(8;14)/t(2;8)/t(8;22) –> c-MYC

A

Burkitt Lymphoma

11
Q

Starry-Sky Pattern (tingle-body macrophages)

A

Burkitt Lymphoma

12
Q

What type of cells have CD10/BCL6

A

Germinal Center B-Cells

13
Q

B cell neoplasm assoc. w/ GI masses & jaw abscess

A

Burkitt Lymphoma

14
Q

Associated w/ EBV and KSHV/HHV-8

CD10/BCL6 cells

A

DLBCL

15
Q

CD4+ T-Cells
Assoc: HTLV-1 infection; Progressive Demyelinating Disease of the CNS
Cloverleaf/Flower cells (multilobated nuclei)

A

Adult T-Cell Leukemia/Lymphoma

16
Q

Cerebriform T-Cells and Eosinophils

CLA+, cause Exfoliative Erythroderma

A

Mycosis Fungoides/Sezary Syndrome

17
Q

STAT3, abundant blue cytoplasm

Assoc: Felty Syndrome (RA, Splenomegaly, Neutropenia)

A

Large Granular Lymphocytic Leukemia

18
Q

CD2/3/5+ Lymphoma

Eosinophils, Macrophages, Angiogenesis, LN effacement

A

Peripheral T-Cell Lymphoma, unspecified

19
Q

CD30, ALK+

large Hallmark T-Cells (horseshoe nucleus, voluminous cytoplasm), vascular clustering

A

Anaplastic Large-Cell Lymphoma

20
Q

Aggressive Lymphoma w/ only NK-cell markers (CD56)

Azurophilic granules, pyknotic nuclei, ischemic necrosis

A

Extranodal NK/T-Cell Lymphoma

21
Q

CD15/CD30/PAX5 Lymphoma

A

Classical Hodgkin Lymphoma

22
Q

CD20/BCL6 Lymphoma

A

Non-Classical Lymphoma

23
Q

Most common Infection with Hodgkin Lymphoma

A

EBV

24
Q

CD138, Syndecan-1, Russel Bodies, Dutcher Bodies

IgG M-protein spike, lytic lesions (hypercalcemia), kappa light chains (Bence-Jones proteins), Rouleaux formation, ,

A

Multiple Myeloma

25
Q

MYD88, PAS+, CD20, Russel Bodies, Dutcher Bodies

IgM hyperviscosity, splenomegaly, NO bone destruction or renal failure

A

Lymphoplasmacytic Lymphoma (Waldenstrum Macroglobulinemia)

26
Q

t(15;17)/M3/WHO 1, MPO+, Auer Rods

A

Acute Promyelocytic Leukemia (APL) = granulocytosis w/ left shift

27
Q

inv(16)/M4/WHO 1, Esterase+, Leukemia Cutis, mucosal hemorrhages

A

Acute Monocytic Myelogenous Leukemia (AMML) = monocytosis

28
Q

t(8;21)/M2/WHO 1

A

AML

29
Q

Monosomy 5,7; Deletion 5q,7q,20q; Trisomy 8

A

Myelodysplastic Syndromes

30
Q

RBC: Ring Sideroblasts
Neutrophils: Bi-lobate, Dohle Bodies, Pseudo-pegler-huet cells
Megakaryocytes: large, pawn ball megakaryocytes
Giant platelets

A

Myelodysplastic Syndrome

31
Q

t(9;22) –> BCR-ABL

A

CML or adult B-ALL

32
Q

JAK2 w/ increased RBC, Granulocytes, Platelets (Panmyelosis), low EPO

A

Polycythemia Vera (myeloproliferative)

33
Q

JAK2, MPL, Reticulin w/ increased platelets only

A

Essential Thrombocytosis (Myeloproliferative)

34
Q

JAK2, MPL, Reticulin w/ BM fibrosis, Leukoerythroblastosis (tear-drop cells)

A

Primary Myelofibrosis

35
Q

Birbeck Granules, BRAF, HLA-DR, S-100, CD1a

A

Langerhans Cell Histiocytosis