Patho - diseases of salivary glands

Question 1

Sialadenitis is ……….

Answer 1

Inflammation of salivary glands

Question 2

Causes of Sialadenitis

Answer 2

• ductal obstruction
• infection
• autoimmune disease

Question 3

Common infectious disease in parotid glands

Answer 3

Mumps (epidemic parotitis)

Question 4

Causative organism of mumps

Answer 4

paramyxo virus

Question 5

Clinical Picture of mumps

Answer 5

Unilateral or bilateral enlargement of the parotid

Question 6

Microscopic picture of mumps

Answer 6

Infiltration of lymphocytes and histocytes ( MQ)

Question 7

Complications of mumps

Answer 7

• in children: self-limited
• In adult: orchitis, oopheritis, pancreatitis

Question 8

Bacterial sialadenitis Is most common in

Answer 8

submandibular glands

Question 9

Causative organism of Bacterial sialadenitis is

Answer 9

staphylococci and streptococci

Question 10

Predisposing factors of Bacterial sialadenitis

Answer 10

Obstruction of the duct by stones

Question 11

Sialolithiasis (Salivary calculi) Most common in ………

Answer 11

the submandibular duct

Question 12

The stone In Sialolithiasis is formed of ……………..

Answer 12

formed of a nidus of :

• desquamated ductal epithelium
• Inspissated secretion
• calcium phosphate

Question 13

Clinical picture of Sialolithiasis

Answer 13

Pain, enlargement of the gland at meal time due to accumulation of

secretion

Question 14

Sjogren syndrome is an

Answer 14

It is an autoimmune disease

Question 15

Pathogenesis of Sjogren syndrome

Answer 15

destruction of lacrimal and salivary glands

Question 16

Clinical picture of Sjogren syndrome

Answer 16

• Dry eye keratoconjunctivitis
  sicca
• Dry mouth xerostomia

Question 17

Etiology of Sjogren syndrome

Answer 17

2ry form associated with rheumatoid arthritis

Question 18

Serology in Sjogren syndrome shows

Answer 18

Anti Ro / SSA antibody

Anti La / SSB antibody

Question 19

Complications of Sjogren syndrom

Answer 19

B-cell lymphoma ( non - Hodgkin lymphoma)

Question 20

Microscopic picture of Sjogren syndrome

Answer 20

• Atrophy of acini
• Loss of architecture
• Lymphoplasmacytic infiltrate ———-> lymphoid follicles

Question 21

Benign tumors of Salivary Glands

Answer 21

1. Papillary cystadenoma lymphomatosum [Warthin›s tumor]
2. Pleomorphic adenoma [mixed salivary tumor]

Question 22

Gross of Papillary cystadenoma lymphomatosum [Warthin›s tumor]

Answer 22

large cystic areas

Question 23

Microscopic picture of Papillary cystadenoma lymphomatosum [Warthin›s tumor]

Answer 23

covered by columnar oncocytes

Question 24

The most common tumor of salivary glands

Answer 24

Pleomorphic adenoma [mixed salivary tumor] ( benign)

Question 25

Pleomorphic adenoma [mixed salivary tumor] Affect which salivary gland ?

Answer 25

Parotid

Question 26

Predisposing factors of Pleomorphic adenoma [mixed salivary tumor]

Answer 26

Male > female

Question 27

Gross of Pleomorphic adenoma [mixed salivary tumor]

Answer 27

Encapsulated, firm, multinodular

Question 28

Why Pleomorphic adenoma [mixed salivary tumor] recurrent ?

Answer 28

Due to failure to recognize extension of tumor beyond

Question 29

Microscopic picture of Pleomorphic adenoma [mixed salivary tumor]

Answer 29

- Epithelial tissue : 1) Solid sheets or strands of epithelial cells . 2) Spindle-shaped myoepithelial cells . - Mesenchymal tissue : 3) Myxomatous CT . 4) Cartilage or pseudo cartilage .

Question 30

Malignant tumors of Salivary Glands

Answer 30

1) Carcinoma in pleomorphic adenoma 2) Adenoid cystic carcinoma (Teratoma) 3) Mucoepidermal carcinoma

Question 31

In Carcinoma in pleomorphic adenoma Malignant change…………..with time

Answer 31

Increase

Question 32

Carcinoma in pleomorphic adenoma Takes the form of

Answer 32

adenocarcinoma or undifferentiated carcinoma

Question 33

Adenoid cystic carcinoma (Teratoma) found in

Answer 33

submandibular and minor salivary gland

Question 34

Microscopic picture of Adenoid cystic carcinoma (Teratoma)

Answer 34

- Perineural invasion is common - Swiss - cheese apperance

Question 35

Commonest primary malignant tumour of salivary glands is

Answer 35

Mucoepidermal carcinoma

Question 36

Mucoepidermal carcinoma affect

Answer 36

parotid

Question 37

Microscopic picture of Mucoepidermal carcinoma

Answer 37

consists of mucous & cysts