Patho-Infectious

Question 1

Warthin-Finkeldey Cells

• multinucleated giant cells
• eosinophilic nuclear and cytoplasmic inclusions

Answer 1

MEASLES

Question 2

Organs affected by MUMPS

Answer 2

CNS, Parotid, Testes

-with mononuclear infiltrates

Question 3

Cowdry Type A

-pink to purple intranuclear inclusion bodies

Answer 3

HSV

Question 4

Dewdrops on Rose Petal

-intraepithelial vesicles

Answer 4

VZV

Question 5

Owl’s eye

• intranuclear, basophilic with clear halo
• large cells with ATYPIA

Answer 5

CMV

-heterophile negative

Question 6

Transforming virus

-paracortical hyperplasia

Answer 6

EBV

• heterophile positive
• causes mononucleosis

Question 7

Causes

• granulomatosis infatiseptica
• chorioamnionitia

Answer 7

Listeria monocytogenes

-Gram + bacilli

Question 8

Fleur-de-list pattern

• pale necrotic centers
• red, hemorrhagic periphery

Answer 8

Pseudomonas

• perivascular blue haze
• coagulative necrosis

Question 9

Donovan bodies

-Giemsa/Warthin-Starry stain

Answer 9

Klebsiella granulomatis

-granuloma inguinale

Question 10

IL-12 -> APC -> TH1 -> macrophage, granuloma, caseation necrosis

Depressed CMI: accumulation of AFB

Answer 10

PTB

1 Ghon focus, Ghon complex (LN involvement)
2 Simmon focus
Pulmonary progressive (involvement of vasculature)
3 Miliary pulmonary

Question 11

Intact CMI
Lepromin +
TH1
Asymmetric peripheral nerve involvement
Granulomatous

Answer 11

Tuberculoid

-paucibacillary

Question 12

Depressed CMI
Lepromin -
TH2
Antibodies cause GN (type 3 hypersensitivity)
Lipid- laden macrophages

Answer 12

Lepromatous

• multibacillary
• Lepra cells

Question 13

1 Chancre
2 Mucocutaneous
3 Neurosyphilis, gummas, aortitis

Answer 13

Treponema pallidum

Question 14

Congenital Syphilis Triad

Answer 14

Interstitial keratitis
Hutchinsons teeth
Eight nerve deafness

Question 15

Gas gangrene

Answer 15

Clostridium perfringes

• alpha toxin
• lecithinase

Question 16

Mucopurulent exudate reminiscent of a volcano

Answer 16

Clostricium difficile

Question 17

L Strains (Lymphogranuloma venereum)

Answer 17

Chlamydia trachomatis

Question 18

Thrush

Answer 18

Candida albicans

-pseudohyphae

Question 19

Mucicarmine +

Soap bubble lesion in CNS in immunocompromised, granulomatous in immunocompetent

Answer 19

Cryptococcus neoformans

Question 20

Septate hyphae

Acute

Answer 20

Aspergillus

Question 21

Nonseptate hyphae

Right angle

Answer 21

Mucor

Question 22

Parasite with hemozoin

Answer 22

Plasmodium

• in asexual stage
• Malaria

Question 23

Parasite without hemozoin

With MALTESE CROSS pattern

Answer 23

Babesia

-Babesiosis

Question 24

Visceral: Kala-azar (hyperpigmentation)
Cutaneous: granulomatous
Diffuse cutaneous: foamy macrophage

Answer 24

Leishmaniasis

Question 25

Affects heart and ganglion Causes dilated cardiomyopathy Megacolon Megaesophagus

Answer 25

Trypanosomiasis American - T. Cruzi

Question 26

Demyelinating panencephalitis (leptomeningitis) Hemolymphatic spread

Answer 26

African | T. bruceii

Question 27

Penetration to skin > lungs > GIT Autoinfection in GIT

Answer 27

Strongyloides stercoralis | -nematode

Question 28

Encyst muscles with richest blood supply "Nurse Cells" in skeletal muscles

Answer 28

Trichinosis | -nematode

Question 29

Lymphedema Elephantiasis

Answer 29

Filiariasis -nematode With Meyers-Kouwenaar bodies - dead worms surrounded by hyaline, eosinophili precipitates

Question 30

Affects skin and eye Skin: leopard or lizard or elephant skin; subcutaneous nodule Eye: Mazzotti reaction, iridocyclitis and glaucoma, atrophy and loss of vision

Answer 30

Onchocerca volvulus | -nematode

Question 31

Infective stage: cercaria Eggs > bowel and bladder wall

Answer 31

Schistosoma japonicum and mansoni -pipestem fibrosis (bowel) Schistosoma heamatobium - bladder wall - granulomatous cystitis - inc. Risk of bladder squamous cell CA

Question 32

Hydatid disease | -carefully removed by surgeon to avoid rupture

Answer 32

Echinococcus granulosus | -cestode

Question 33

Pathologic lesion: Cystecerci With scolex

Answer 33

Taenia solium | -cestodes