Pathogeneic factors of Disease in nervous system

Question 1

What is NanA?

Answer 1

Streptococcus pneumonia use it to penetrate the blood brain barrier to cause bacterial meningidis.

Question 2

What is capsule antigen type B

Answer 2

HAemophilus influenzae or Hib has a antigen type B that is easily indentifiable.

Question 3

Describe the pathogenic factors of Neisseria Meningitis.

Answer 3

IgA protease
Endotoxin
Pili
LOS- lacks O antigen and contains siaclic acid
In meninggitis of neisseria.

Question 4

What is Tetanospasmin?

Answer 4

A toxin present in tetanus.
It binds to GT1b- motor nuerons gangliosides
it degrades snaptobrevin II in presymtatpic membranes of nerves. This causes the release of Glycine and GABA.
In tetanus

Question 5

What is botulism toxin?

Answer 5

It is a toxin carried to the perperihal nerves by the blood stream
It also binds GT1b and degrades SNAP 25 which is responsible for releasing acetyl choline. In botulism

Question 6

What are G spikes?

Answer 6

THey are a glycoprotein that allows the attachment of the enveloped virus to perpheral neruons proteins or p75NTR. IN rabies