Pathology Flashcards
(25 cards)
TTF1
lung and thyroid
WT1
peritoneal lining and serous
CD10
endometrial stroma
sarcomatous overgrowth
One 4X field without glands
what does WT1 help differentiate between?
gyn and breast; + for serous gyn tumors
endocervical glands
apical mucin that appears blue gray; not seen in endometrial glands
normal pap smear cell morphology
low N/C ratio; pink = estrogen stimulated; blue = progesterone stimulated
endometrial hyperplasia
> 55% gland to stroma ratio
endometrioid adenocarcinoma grading
5-50% solid = grade 2
>50% solid = grade 3
serous histogy buzz word
“ships in the night”
p53 nuclear stain
mutated p53 has more abnormal p53 around; thus there is increased staining in a p53 mutated tumor; this can correlate to more agressive tumor behavior
foamy cells within stroma
dead cells that have been devoured by macrophages
typical stain panel in gyn
ER/PR/CEA/vimentin
vimentin
mesenchymal/stromal; stains + in endometrium
p16
cervical tumors
villoglandular
fibrovascular chords
CDX2
specific to colon ca; if CK20+ think GI
hematoxalyn
nuclear stain
eosin
cytoplasm and stromal stain
PAS
general stain for fungal elements; green background
endocervical adeno ca
CK7+/CK20 -, CEA+
mucinous ovarian ca
CK7+/CK20+ (CDX2 variable
endometrial adeno ca
CK7+/CK20-, vimentin +, ER/PR+
SCC of the cervix
CK7+/CK20-
