Pathology 2 Flashcards
(17 cards)
What is the most common benign fat tumor?
Lipoma.
What genetic abnormality is associated with liposarcoma?
MDM2 amplification.
What tumor is a rapid but self-limiting fibroblastic proliferation?
Nodular fasciitis.
Which fibrous tumor is associated with APC mutations (Gardner syndrome)?
Fibromatosis (Desmoid tumor).
Which soft tissue sarcoma shows a “herringbone pattern” histologically?
Fibrosarcoma.
Which tumor is CD34 positive and grows slowly but invades deeply?
Dermatofibrosarcoma Protuberans (DFSP).
What is the most aggressive high-grade sarcoma with pleomorphic cells?
Undifferentiated Pleomorphic Sarcoma (UPS).
What is the genetic defect in Duchenne Muscular Dystrophy?
Absent dystrophin (X-linked recessive).
How does Becker Muscular Dystrophy differ from Duchenne?
Dystrophin is reduced or abnormal; milder course.
What type of atrophy shows angulated muscle fibers?
Neurogenic atrophy.
Which muscle disease presents with symmetric proximal weakness and skin rash?
Dermatomyositis.
Which inflammatory muscle disease involves endomysial inflammation?
Polymyositis.
Which disorder improves muscle strength with repeated use?
Lambert-Eaton Myasthenic Syndrome (LEMS).
In Myasthenia Gravis, where are the antibodies directed?
Against acetylcholine receptors (AChR).
Which disease involves muscle cramps after short intense exercise due to glycogen breakdown defect?
McArdle Disease (Glycogen Storage Disease Type V).
Which deficiency impairs fat transport into mitochondria for energy?
Carnitine deficiency.
What is a key microscopic finding in mitochondrial myopathies?
Ragged red fibers.
