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Flashcards in Pathology Deck (29):
1

Tau protein aggregates

Alzheimer
Pick dz

2

Spares parietal lobe and posterior 2/3 of temporal lobe

Pick dz

3

Neurofibrillary tangles

Alzheimer

4

Alpha-synuclein defect

Lewy body dementia

5

Spongiform

CJ

6

APP gene mutation

Alzheimer (early onset)

7

Rapid progression w/in weeks to months

CJ

8

Visual hallucinations

Lewy body dementia

9

ApoE4 gene mutation

Alzheimer (late onset)

10

Parkinsonian features

Lewy body dementia
Pick dz

11

Startle myoclonus

CJ

12

Assoc w/ Down syndrome

Alzheimer

13

Beta amyloid plaques

Alzheimer

14

High susceptibility to neuroleptic agents (neuroleptic malignant syndrome)

Lewy body dementia

15

Presinilin-1 (gamma secretase) or presinilin-2 mutations

Alzheimer

16

Destruction of oligodendrocytes in AIDS pt

Progressive multifocal leukodystrophy

17

Arylsulfatase A deficiency

Metachromatic leukodystrophy

18

Scoliosis + foot deformities

Charcot-Marie-Tooth

19

Deficient galactocerebroside

Krabbe

20

Defective metabolism of very long chain fatty acids

Adrenoleukodystrophy

21

Type IV hypersensitivity rxn against oligodendrocytes

MS

22

Activating GNAQ mutation

Sturge-Weber

23

Birthmark in V1/V2 distribution

Sturge-Weber

24

Benign hemartomas in CNS and skin

Tuberous sclerosis

25

Ash-leaf spots

Tuberous sclerosis

26

Angiomyolipomas

Tuberous sclerosis

27

Cafe-au-lait spots

NFT 1

(von Recklinhausen)

28

Pigmented iris hamartomas

NFT 1

(von Recklinghausen)

29

Bilateral renal cell carcinoma

von Hippel-Lindau