Flashcards in Pathology Deck (26):
What grade meningioma are rhabdoid / papillary subtypes?
What grade is a clear cell and chordoid meningoma?
What is EMA?
Epithelial membrane antigen - positive with meningiomas
What grade is a haemangiopericytoma?
Grade 2 aka solitary fibrous tumour
What is synaptophysin?
An immunostain for a neuronal lineage
What are the histological features of a central neurocytoma?
Similar features to an oligodendroglioma byt synaptophysin postive and 1p19q negative; If neurofilament positive then ganglioneurocytoma.
What immune markers are found with germinomas?
PLAP and c-Kit
What rosettes are found with pineocytomas?
What are the histological features of an adamantinomatous craniopharyngioma?
MIcroscopic and macroscopic cysts, cholesterol rich, can be adhesed to brain tissue and have Rosenthal fibres
What is the origin of craniopharyngioma?
Remnant of Rathke's pouch
What age group do adamantinomatous craniopharygiomas arise?
Children (papillary are in adults)
What mutation occurs with adamantinomatous craniopharyngiomas?
CTNNB1 which encodes beta-catenin in the Wnt pathway;
(BRAF mutation occurs in 95% of papillary craniopharyngiomas)
What mutation is found with pilocytic astrocytoma?
BRAF fusion gene
What mutation is found with low grade astrocytoma?
ATRX and TP53
What mutation is found with low grade oligodendroglioma?
What is the role of IDH-1?
Normal IDH-1 converts isocitrate to alpha-ketoglutarate; The mutated form makes 2-hydroxyglutarate which causes tumour formation;
How can a low grade glioma be distinguished from an ependymoma?
What is the prognostic significance of IDH-1?
If mutated carries a better prognosis
What mutation is characteristic of a diffuse astrocytoma?
What is ATRX?
This is a chromatin regulator and missense mutations are found in 70% of Gd2&3 astrocytomas.
What type of tumour has a FUBP1/CIC mutation?
What is CIMP?
CpG island promoter methylation and is associated with tumour subgroups that has impact on prognosis. CIMP is found with oligodendroglioms.
A GBM with reticulin and vimentin positive. What is the diagnosis?
What is a SNUC?
Sinonasal undifferentiated carcinoma
What are the patterns of metastatic spread?
1) Intracerebral; 2) Leptomeningeal and 3) Epidural mass