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Flashcards in PATHOLOGY Deck (61):
1

Most common form of testicular neoplasm in men > 60 years of age

Testicular lymphoma

2

Sex cord-stromal tumor with Crystalloids of Reinke (25%)

Leydig Cell Tumor

3

Embryonal Carcinoma with Schiller-Duval Bodies/glomeruloid (50%)

Yolk Sac Tumor

4

Tumor marker for prostatic adenocarcinoma when PSA is elevated but with normal biopsy

PCA 3 (Prostate Cancer Gene 3)

5

Most common site of prostate adenocarcinoma metastasis

Lumbar spine 》 proximal femur 》 pelvis 》 thoracic spine 》 ribs

6

Tennis racket cytoplasmic organelles

Birbeck granules/bodies in Langerhans cell histiocytosis

7

HPV type in condyloma acuminata

HPV 6, 11

8

Most common etiologic agents for pelvic inflammatory disease

Gonococcus and Chlamydia

9

Visual inspection of cervix with Lugol's solution? High risk for cervical cancer if?

Schiller Test. (+) Pale staining areas

10

Schedule of Papanicolaou Smear

Start at 21 or within 3 years after first coitus, every 3 years until 30

11

Most common malignant germ cell tumor in females

Dysgerminoma

12

Second most common malignant germ cell tumor in females

Yolk sac tumor

13

Tumor marker for dygerminoma

KIT

14

Tumor marker for yolk sac tumor

AFP

15

Tumor marker for ovarian choriocarcinoma

HCG

16

Hydrothorax, ascites, ovarian tumor

Meig Syndrome

17

Sex-chord stromal tumors with Call-Exner bodies

Granulosa cell tumor

18

Signet ring GI carcinoma metastatic to the ovaries

Krukenberg tumor

19

Discohesive infiltrating tumor cells in single file (Indian file)

Invasive lobular carcinoma

20

Most common benign tumor of female breast

Fibroadenoma (stromal tumor)

21

Most common genetic abnormality in phyllodes tumor (stromal tumor)

Gains in Ch1q

22

Granulomatous thyroiditis causing thyrotoxicosis

De Quervain thyroiditis

23

Ovarian teratoma with ectopic thyroid causing thyrotoxicosis

Struma ovarii

24

MCC of congenital hypothyroidism worldwide

Congenital iodine deficiency

25

MCC of hypothyroidism in iodine-sufficient areas

Hashimoto (Autoimmune)

26

Metaplastic response characterized by abundant, eosinophilic, granular cytoplasm in Hashimoto

Hurthle cell

27

Thyroid carcinoma with high levels of calcitonin but usually without hypocalcemia

Medullary thyroid carcinoma

28

Increase osteoclastic activity, peritrabecular fibrosis, cystic brown tumors

Von Recklinghausen disease of the bone

29

Nodular glomerulosclerosis of diabetes mellitus

Kimmelsteil-Wilson Disease

30

Massive bilateral adrenal hemorrhage as a complication of disseminated bacterial infection

Waterhouse-Friedrichsen Syndrome (Primary Acute Adrenocortical Insufficiency)

31

Bacteria associated with Waterhouse-Friedrichsen Syndrome

N. meningitidis

32

Cytogenetic origin of pheochromocytoma

Chromaffin cells

33

Rule of 10s in pheochromocytoma

10% extra-adrenal, 10% bilateral, 10% malignant, 10% NOT associated with hypertension

34

Prolactinoma (pituitary), Primary Hyperparathyroidism (parathyroid), Insulinoma or Gastrinoma (pancreas)

MEN 1 (Wermer Syndrome)

35

Mutation in Wermer Syndrome

MEN 1

36

MEN associated with parathyroid hyperplasia

MEN 2A (Sipple Syndrome)

37

MEN associated with neuromas, gangliomas, and Marfanoid habitus

MEN 2B

38

MEN 2 mutations

RET

39

Rapid increase in seborrheic keratosis as paraneoplastic syndrome of GI malignancies

Leser-Trelat sign

40

Lesions appear on sites of trauma in psoriasis

Koebner Phenomenon

41

Pinpoint bleeding on lifting of scales due to dilated tortuous vessels in dermal papillae

Auspitz Sign (Psoriasis)

42

Inflammatory infiltrates in psoriasis

Spongiform pustules of Kogoj and Munro microabscess

43

Impaired osteoclast function leads to excessive bone formation

Osteopetrosis (Marble Bone Disease) aka Albers-Schonberg Disease

44

First disorder to be treated with hematopoeitic stem cell transplantation

Osteopetrosis

45

Most common inherited disorder of connective tissue

Osteogenesis Imperfecta (Brittle Bone Disease)

46

Most common benign tumor of the liver

Hemangioma

47

Autosomal recessive disorder of copper metabolism

Wilson disease (hepatolenticular degeneration)

48

Oncogene activated in Pancreatic intraductal neoplasia 1A and 1B

KRAS oncogene

49

Gene mutation in PanIN2

p16 mutation

50

Gene mutation in PanIN3

p53, BRCA2, DPC4/SMAD4

51

Migratory thrombophlebitis in adenocarcinoma of the pancreas (sign)

Trousseau sign

52

Also known as strawberry gallbladder (yellow cholesterol-containing flecks in GB mucosal surface

Cholesterolosis

53

Also known as strawberry gallbladder (yellow cholesterol-containing flecks in GB mucosal surface)

Cholesterolosis

54

Apoptotic hepatocytes first identified in yellow fever

Councilman bodies

55

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

55

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

55

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

56

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

56

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

56

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies

56

Intracytoplasmic eosinophilic hyaline inclusions in alcoholic hepatitis

Mallory bodies