Pathology

Question 1

Glucocorticoid MoA on chronic ITP

Answer 1

Inhibits phagocyte function, therefore preventing digestion of plt opsonised by IgG Ab

Question 2

Common drugs causing drug-induced thrombocytopenia

Answer 2

Vancomycin

Quinine

Quinidine

Question 3

Major causes of DIC

Answer 3

1. Malignancy
2. Obstetric Cx
3. Major trauma
4. Sepsis
5. Major surgery

Question 4

Pathological factor in DIC in sepsis

Answer 4

TNF

Induces endothelial cells to express tissue factor on their cell surfaces + to reduce thrombomodulin expression

Question 5

Triggers for DIC

Answer 5

1. Release of tissue factor / thromboplastin substances into the circulation
2. Widespread inj to endothelial cells

Question 6

Pathological process of DIC

Answer 6

1. Widespread deposition of fibrin within microcirculation -> ischemia + microangiopathic haemolytic anaemia
2. Consumption of plt + CFs + activation of plasminogen