Pathology-Duval 4/2/14 Flashcards Preview

Clin Med-Endocrine > Pathology-Duval 4/2/14 > Flashcards

Flashcards in Pathology-Duval 4/2/14 Deck (24):
1

what is the adenohypophysis derived from

the oral cavity

2

what are the three types of cells the adenohypophysis made up of

basophili, eosinophilic, chromophobic

3

what is the neurohypophysis made up of

pituicytes (glial cells)
axonal processes from hypothalamus

4

what is the most common cause of hyperpitutiatarism

functional neoplasm

5

what are other causes of hyperpituitarism?

hyperplasia, carcinoma, nonpituitary tumor

6

what are some clinical side effects of functional adenoma

bitemporal hemianopsia, erode bone, hermorrhage, increased intracranial pressure, hypopiutarism

7

what is the most common of the functional adenomas

prolactinomas

8

what is the second most common cause of functional adenoma

somatotroph adenoma

9

who will you see prolactinomas in

earlier in premonopausal females
macroadenomas in males,
amenorrhea, galactorrhea, libido, infertility

10

what are the presentations of somatotroph

macroadenomas, gigantism or acromegaly

11

what are the causes of hypopituitarism

ischemic necrosis, radiation ablation, inflammation, nonfunctional adenoma, trauma, meastases, empty sella syndrome

12

what is the cause of empty sella syndrome

chronic herniation of subarachnoid space through defect in diaphragma

13

what is the etiology of SIADH

small cell lung cancer, other lung diseases, local injury

14

what are features of SIADH

hyponatremia, cerebal edema

15

what is the thyroid gland made from

follicular epitherlim and C-cells

16

what is the cause of thyrotoxicosis

hypermetabolic state due to elevated free thyroid hormones

17

what is the most common cause of hyperthyroidism

graves disease

18

what is the clinical triad of graves disease

throtoxicosis, exopthalmos, pretibial myxedema (swelling/ waxy skin

19

what is nonspecific lymphocytic thyroiditis

incidential finding in middle aged females
HLA DR5
features transient thyrotoxicosis due to incereased hormone release
increased free hormones, decreased TSH, decreased uptake

20

what is the morphology of hasimotos thyroiditis

diffuse symmetric enlargment
mononuclear cell infiltrate
hurthle cells
variable fibrosis
reduced free hormone increase TSH

21

What is the features of subacute granulomatous thyroiditis

acute onset and self limited
pain, fever, malaise
elevated EBC, ESR
found in young to middle aged females with antecedent viral infection

22

what is the most common subtype of carcinoma

papillary
associated with ionizing radiation
orphan annie eyes are characteristic

23

follicular carcinoma

second most common thyroid cancer
NOT an adenoma
cold nodule

24

what is the morphology of medullary carcinoma

middle aged to elderly
degenerative changes
spindle of polygonal cells
amyloid deposits
cacitonin positive
C cell hyperplasia