Pathology Findings

Question 0

Findings in Coeliac disease?

Answer 0

Crypt hyperplasia with inflammatory cells in the mucosa

Total or subtotal villous atrophy

Question 1

Findings in Barrett’s oesophagus?

Answer 1

Metaplasia of lower oesophageal epithelium to gastric- or intestinal-type epithelium

Question 2

Findings in Crohn’s disease?

Answer 2

Macroscopic: skip lesions, cobblestone appearance, fissured ulcers
Microscopic: thickened wall, transmural inflammation, granulomas

Question 3

Findings in Ulcerative Colitis?

Answer 3

Mucosal/submucosal inflammation only, crypt abscesses, superficial ulceration

Question 4

Findings in Chronic Cholecystitis?

Answer 4

Chronic inflammatory changes

Rokitansky-Aschoff sinuses

Question 5

Findings in acute viral hepatitis?

Answer 5

Swelling of hepatocytes with spotty necrosis

Councilman bodies

Question 6

Findings in alcoholic hepatitis?

Answer 6

Fatty accumulation in cytoplasmic vacuoles, necrosis, Mallory hyaline material

Question 7

Findings in chronic active hepatitis?

Answer 7

Piecemeal necrosis

Question 8

Findings in autoimmune hepatitis?

Answer 8

Interface hepatitis, portal plasma cell infiltration

Question 9

Findings in haemochromatosis?

Answer 9

Excessive hepatic iron visible as Blue on Perl’s stain

Question 10

Findings in primary biliary cirrhosis?

Answer 10

Portal hepatitis, granulomatous destruction of bile ducts.

Later: periportal hepatitis and bile duct proliferation.

Question 11

Findings in liver cirrhosis?

Answer 11

Macroscopic: macro-/micronodular
Microscopic: fibrous tissue visible as red on von Gieson stain

Question 12

Findings in diffuse alveolar damage?

Answer 12

Alveolar hyaline membranes, thickened alveolar walls

Question 13

Findings in previous asbestos exposure?

Answer 13

Asbestos bodies

Question 14

Findings in pulmonary fibrosis?

Answer 14

Proliferation of Type II pneumocytes, thickening of alveolar walls

Question 15

Finding on renal biopsy in malignant hypertension?

Answer 15

Renal arteriolar fibrinoid necrosis

Question 16

Findings on renal biopsy in diabetic glomerulosclerosis?

Answer 16

Kimmelstein-Wilson nodules, thickened capillary basement membranes, hyalinisation of arterioles

Question 17

Findings in Hosgkin’s Disease?

Answer 17

Reed-Sternberg cells, abnormal lymph node architecture

Nodular sclerosing type has fibrous tissue

Question 18

Findings in myelofibrosis?

Answer 18

Bone marrow fibrosis 2ry to fibroblast proliferation

Question 19

Findings in Multiple Myeloma?

Answer 19

Plasma cell proliferation in bone marrow

Question 20

Findings on temporal artery biopsy in temporal arteritis?

Answer 20

May be normal

May have plasma cells, lymphocytes and multinucleate giant cells

Question 21

Findings in Polymyositis?

Answer 21

Muscle fibre necrosis

Lymphocyte infiltration

Question 22

Findings in acromegaly?

Answer 22

Pituitary acidophil macroadenomas (somatotroph adenomas)

Question 23

Findings in hyperprolactinaemia?

Answer 23

Pituitary chromophobe adenomas

Question 24

Findings in raised ACTH?

Answer 24

Pituitary basophil microadenomas (corticotroph adenomas)

Question 25

Findings in Alzheimer’s Disease?

Answer 25

Macroscopic: thinning of gyri
Microscopic: neurofibrillary tangles, plaques

Question 26

Findings in Parkinson’s disease/DLB?

Answer 26

Lewy Bodies (inclusion bodies)

Question 27

Findings in ovarian endometriosis?

Answer 27

Macroscopic: chocolate cyst