Pathology - HTN in Pregnancy Flashcards
(23 cards)
Definition of Gestational hypertension (pregnancy-induced hypertension)
BP > 140/90 mm Hg after 20th week of gestation. No pre-existing hypertension. No proteinuria or end-organ damage
Definition of Gestational hypertension (pregnancy-induced hypertension)
BP > 140/90 mm Hg after 20th week of gestation. No pre-existing hypertension. No proteinuria or end-organ damage
Treatment for Gestational Hypertension?
Hypertensive Moms Love Nifedipine.
Treatment: antihypertensives (Hydralazine, α-Methyldopa, Labetalol, Nifedipine), deliver at 37–39 weeks.
Definition of Pre-Eclampsia
New-onset hypertension with either proteinuria or end-organ dysfunction after 20th week
of gestation
What looks like pre-eclampsia but occurs
What causes pre-eclampsia
Caused by abnormal placental spiral arteries -> endothelial dysfunction, vasoconstriction,
ischemia.
Risk factors for pre-eclampsia? (4)
Incidence in patients with pre-existing
hypertension, diabetes, chronic renal disease,
autoimmune disorders.
Treatment of Pre-Eclampsia? (3) what is the definitive treatment?
Treatment: antihypertensives, IV magnesium sulfate (to prevent seizure); definitive is delivery of fetus.
Treatment of Pre-Eclampsia? (3) what is the definitive treatment?
Treatment: antihypertensives, IV magnesium sulfate (to prevent seizure); definitive is delivery of fetus.
Treatment for Gestational Hypertension?
Hypertensive Moms Love Nifedipine.
Treatment: antihypertensives (Hydralazine, α-Methyldopa, Labetalol, Nifedipine), deliver at 37–39 weeks.
Definition of Pre-Eclampsia
New-onset hypertension with either proteinuria or end-organ dysfunction after 20th week
of gestation
What looks like pre-eclampsia but occurs
What causes pre-eclampsia
Caused by abnormal placental spiral arteries -> endothelial dysfunction, vasoconstriction,
ischemia.
Risk factors for pre-eclampsia? (4)
Incidence in patients with pre-existing
hypertension, diabetes, chronic renal disease,
autoimmune disorders.
Complications of pre-eclampsia? (6)
Complications: placental abruption,
coagulopathy, renal failure, uteroplacental insuffciency, eclampsia, HELLP Syndrome
Treatment of Pre-Eclampsia? (3) what is the definitive treatment?
Treatment: antihypertensives, IV magnesium sulfate (to prevent seizure); definitive is delivery of fetus.
Definition of Eclampsia
Preeclampsia + maternal seizures.
Cause of death in Eclampsia
Maternal death due to stroke, intracranial
hemorrhage, or ARDS.
Treatment for Eclampsia
Treatment: IV magnesium sulfate, antihypertensives, immediate delivery.
What is HELLP Syndrome?
Hemolysis, Elevated Liver enzymes,
Low Platelets. A manifestation of severe preeclampsia.
Blood Smear in HELLP Syndrome shows what?
Schistocytes b/c of hemolysis
Major complication of HELLP Syndrome?
Can lead to Hepatic Subcapsular Hematomas which can lead to rupture and subsequent severe hypotension.
Treatment for HELLP Syndrome?
Immediate Delivery
