Pathology of Breast Disease Flashcards Preview

Reproductive System > Pathology of Breast Disease > Flashcards

Flashcards in Pathology of Breast Disease Deck (22)
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1
Q

what is the incidence of breast cancer

A

1 in 8

one quarter of malignancies

2
Q

what are the risk factors for breast cancer

A

genetics BRAC1 BRAC2
previous breast cacner
early menarche and late menopause
HRT

3
Q

what types of bengin breast conditions are there

A
fibrocystic change
fibroadenoma
intrauct papilloma-nipple discharge 
fat necrosis
duct ectasia 
other adenomas
4
Q

what is a fibroadenoma

A
most common tumour 
proliferation of epithelial and stromal elements
small, mobile mass with sharp edges 
not a precursor for cancer
peak age 30s
5
Q

what is an intraduct papilloma

A

tumour of lactiferous ducts

nipple discharge

6
Q

what is phyllodes tumour

A

large bulky mass of connective tissue
leak life projections
some can be malignant

7
Q

what are the risk factors for. breast cancer

A
gener
age
genetics-BRAC1BRAC2
family history
perosonal history 
hormone treatment
8
Q

what are the different types of non invasive

A

ductal carcinoma in situ

lobula carcrinoma in stiu

9
Q

what are the different types of invasive

A

invasive ductal carcinoma

invasive lobular carcnoma

10
Q

what diagnostic procedures are there

A
clinical examiantion
mammogram
USS
MRI
FNA
biopsy
11
Q

what is the screening fro breast cancer

A

very 3 years from 50-70

12
Q

what are microcalcifications

A

tiny deposits of calcium appearing anywhere in the breast and show on mammorgram
some can be cancerous

13
Q

on a mammography what are indicators of cancer

A

masses

microcalficiations

14
Q

what should you record in the histological report

A
invasive vs noninvasive
size
margins 
type-ductal or lobular
lymph nodes
15
Q

what is the spread of breast cancer

A

local
lymphatic
blood

16
Q

what is the local spread of breast cacner

A

skin, pectoral muscles

17
Q

what is the lymphatic spread of breast cancer

A

axillary and internal mammary nodes

18
Q

what is the blood spread of breast cancer

A

bones, lungs, liver and brain

19
Q

what does the prognosis of breast cancer depend on

A
patient status 
nodes
tumour size 
type 
grade 
age
20
Q

what are the molecular markers of breast cancer

A

oestrogen receptors
progesterone receptors
HER2
they show strong response to hormonal therapies

21
Q

what are the 5 types of molecular classification

A
ER
luminal A
luminal B
basal 
HER2 positive 
normal
22
Q

what is pagets disease of the nipple

A

intraepithelial adenocarcinoma

usually comes from DCIS