Pathology of Lung Cancer Flashcards Preview

Systems 1 - The Respiratory System > Pathology of Lung Cancer > Flashcards

Flashcards in Pathology of Lung Cancer Deck (7)
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1
Q

What two locations are involved in the carcinogenesis of the lung?

A

Carcinogenesis in the periphery and the central airways

2
Q

In the lung periphery, what process leads to development of carcinoma?

A

Bronchioalveloar epithelial stem cells transform into adenocarcinoma

3
Q

In the central airways what process leads to development of carcinoma?

A

Bronchial epithelial stem cells transform into squamous cell carcinoma

4
Q

What are the local effects of Lung Cancer?

A
  • Bronchial obstruction
  • Endogenous lipid pneumonia
  • Infection/Abscess
  • Bronchiectasis
  • Pleural inflammation and malignancy
  • Direct invasion
  • Lymph node metastasis
5
Q

What are the distant effects of lung cancer?

A
  • Secondary to local effects (neural and vascular)
  • Paraneoplastic syndrome
  • Clubbing
6
Q

What are the relative proportions of the different histological types of lung cancer?

A

Small cell lung carcinoma (15%)

NSCLC (85%) - not one disease - diagnostic term

7
Q

What are the typical aetiologies for lung cancer?

A
  • Tobacco
  • Asbestos
  • Environmental radon
  • Occupational exposure
  • Air pollution
  • Pulmonary fibrosis