Pathology Of Non-Melanocytic Tumours Flashcards Preview

Dermatology > Pathology Of Non-Melanocytic Tumours > Flashcards

Flashcards in Pathology Of Non-Melanocytic Tumours Deck (15)
Loading flashcards...
1
Q

What are benign epidermal tumours?

A

Seborrhoeic keratosis

2
Q

What are precancerous dysplasias of the epidermis?

A

Bowen’s disease
Actinic keratosis
Viral lesions

3
Q

What are invasive malignancies of the epidermis?

A

BCC AND SCC

4
Q

What is a seborrhoic keratosis?

A

Benign proliferation of epidermal keratinocytes
Common on face and trunk
Stuck on appearance, greasy hyperkeratotic surface

5
Q

What do seborrhoic keratosis look like histologically?

A

Epidermal acanthosis
Hyperkeratosis
Horn cysts
Eruptive appearance of many lesions may indicate internal malignancy (leser trelat sign)

6
Q

What are the different types of BCC?

A

Nodular
Superficial
Infiltrative

7
Q

Where do BCCs originate from?

A
Basal cells sprout epidermis
Groups of cells invade the dermis 
Peripheral palisading
Mitosis and apoptosis very numerous 
Slow growing and locally destructive 
Can kill by invading eye
8
Q

What do basal cell carcinomas look like histologically?

A

Prominent desmoplastic fibrous stroma
Poorly defined margins
Can spread along nerves

9
Q

What is Bowens disease?

A
SCC in situ
Female mostly
Scaly plaque on lower leg
Irregular border
No dermal invasion
10
Q

What is actinic keratosis?

A

Very common on sun exposed skin
Variable epidermal dysplasia
Several atypical lesions are bowenoid

11
Q

What viral precursors can lead to SCC?

A

Viral genital lesions often dysplastic
Erythoplasia of Queryat penile
HPV type 16

12
Q

What can a SCC arise from occasionally?

A

Chronic leg ulcers
Sites of burns
Chronic lupus vulgaris

13
Q

What can SCC arise from rarely?

A

Xeroderma pigmentosum

Dystrophic variant epidermolysis bullosa

14
Q

What are adverse prognosis features of SCC?

A
Thickness over 4mm and poor differentiation
Lymphatic invasion 
Vascular invasion 
Perineural spread
Scalp, ear and nose
15
Q

Where else can tumours arise from in the skin?

A
Dermal connective tissue
Blood vessels
Nerves
Sweat glands
Hair follicles
Smooth muscle arrector pili
Lymphoid tissue 
Langerhans cells 
Merkel cells
Subcutis fat