Pathology of vasculitis Flashcards Preview

Organ Systems- Rheum > Pathology of vasculitis > Flashcards

Flashcards in Pathology of vasculitis Deck (13):
1

Symptoms of vasculitis

fever, myalgias, arthralgias, malaise

2

Signs of vasculitis

palpable purpura, focal skin necrosis, ulceration, livedo reticularis, urticaria, myositis, peripheral neuropathy, GI ulcers/perforations, intussusception. pancreatitis, hemoptysis, nodular pulmonary infiltrates, hematuria, proteinuria, organ ischemia/infarction

3

_____ is network pattern purplish discoloration of skin due to dilation of blood vessels.

Livedo reticularis

4

Signs and symptoms of vasculitis are nonspecific. Vasculitis is a _____ diagnosis.

biopsy

5

What are key features to the specific diagnosis of vasculitis?

distribution of organ involvement, histopathological features

6

Describe the inflammation of temporal arteritis

Segmental, transmural, and granulomatous with multinucleated giant cells centering on internal elastic lamina destroying it. Plus lymphocytes, intimal thickening, cell proliferation, luminal stenosis

7

What are the most common clinical manifestations of temporal arteritis?

1. headache, swollen tender artery, scalp tenderness, visual disturbances, jaw claudication, fevere, malaise, weight loss

8

Describe the inflammation of takayasau arteritis.

Segmental, transmural, necrotizing, loosely granulomatous with multinucleated giant cells with lymphocytes, intimal thickening and adventitial thickening, medial loss of elastic fibers, luminal stenosis

9

Describe the pathology of polyarteritis nodosa.

segmental, transmural, nodular with fibrinoid necrosis.
Neutrophils in acute phase, intimal thickening, cell proliferation and degeneration, luminal stenosis, may have thrombosis, occlusion, or rupture all at branchpoints.

10

Describe the later pathology of polyarteritis nodosa

chronic inflammation, fibroblasts, scarring maybe with aneurysm.

11

Are polyarteritis nodosa lesions hetero or homogenous

hetero

12

What stage of polyarteritis nodosa looks like there are ants crawling all over an artery?

Acute

13

Do you see livedo reticularis in polyarteritis nodosa?

yes