Pathomorphology WORDS Flashcards Preview

PATHOmorphology Final Prep 2016/2017 > Pathomorphology WORDS > Flashcards

Flashcards in Pathomorphology WORDS Deck (53):
1

Anitschkow cells (Caterpillar cells):

Reactive histiocytes (enlarged macrophages), found within granulomas associated with Rheumatic Fever.

2

Aschoff bodies:

Rheumatic fever, in myocardial tissue.

Central area of fibrinoid necrosis surrounded by Anitschkow (caterpillar) cells.

Contains lymphocytes, plasma cells, multinucleated giant cells.

3

Asteroid body:

Stellate inclusions found in giant cells of granulomas in diseases such as sarcoidosis

4

Atheroma:

Fibrous plaque (cap) in atherosclerosis, made of SMCs, foam cells, inflammatory cells, ECM, & lipids.

Overlies a necrotic center

5

Auer rods:

Fused azurophilic granules, present in Acute Myeloblastic Leukemia (AML)

6

Bence Jones protein:

Light chains in urine.

Tumor marker in multiple myeloma and Waldenstrom macroglobulinemia

7

Blue-domed cysts:

Cysts with hemorrhage found in Fibrocystic change (FCC) of breast.

No malignant potential.

8

Brown atrophy:

Brown tissue discoloration caused by accumulation of Lipofuscin in primary lysosomes.

Normal age-related finding in the elderly.

9

Call-Exner bodies:

Found in Granulosa-theca cell tumor

10

Charcot-Leyden crystals:

Found in asthmatics, formed by crystalline granules in eosinophils

11

Chocolate cyst:

Endometrioma; Type of ovarian cyst linked to endometriosis.

12

Clara (club) cells:

Bronchiolar exocrine dome-shaped cells with short microvilli, found in bronchioles.

Most commonly gives rise to Bronchioloalveolar carcinoma (adenocarcinoma of lung)

13

Colles fracture:

Fracture of distal radius in forearm w/ dorsal & radial displacement of wrist and hand.

Often seen in osteoporosis

14

Cord factor:

Virulence factor (protein) produced by TB inside phagosomes of alveolar macrophages, prevents fusion of lysosomes w/ phagosome

15

Councilman bodies:

Apoptotic hepatocyte, found in viral hepatitis

16

Crystals of Reinke:

Found in Pure Leydig cell tumors

17

Curschmann spirals:

Spiral-shaped mucus plugs from subepithelial mucous gland ducts or bronchioles;
Found in sputum of asthmatics

18

Dohle bodies:

Light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils.

19

Dowager's hump:

Kyphosis (forward bending of spine) due to advanced osteoporosis.

Increased risk for Colles fracture of distal radius.

20

Dust cells:

Black, pigmented alveolar macrophages produced by phagocytosis of black anthracotic pigment (coal dust) in Coal worker's pneumoconiosis.

21

Epiphrenic diverticulum:

Above lower esophageal sphincter

22

Fatty streaks:

Grossly visible lesions in the development of atherosclerosis.

Irregular yellow-white discoloration of luminal surface of the artery.

23

Foam cells:

Fat-containing macrophages seen in atherosclerosis, produced when body sends macrophages to location of a fatty deposit on blood vessel walls.

24

Ghon focus:

Caseous necrosis in periphery of lungs found in primary TB

25

Ghon complex:

Caseous necrosis in hilar lymph nodes in primary TB

26

Heart Failure cells:

Alveolar macrophages with Hemosiderin.

Gives sputum a rusty-brown color.

27

Heinz bodies:

Inclusions within RBCs composed of denatured (damaged) hemoglobin (by oxidant damage or from inherited mutation)

28

Kayser-Fleischer ring:

Copper deposits in Descemet membrane of cornea, found in Wilson's Disease (not pathognomonic).

Also found in primary biliary cirrhosis (PBC).

29

Kerley lines:

Thin, linear pulmonary opacities seen on chest radiographs with interstitial pulmonary edema

30

Kulchitsky cells:

Neuroendocrine cells.

Give rise to Small cell Carcinoma (SSC) of lung

31

Kupffer cells:

Stellate macrophages located in liver, lining walls of sinusoids.

Activation => Early ethanol-induced liver injury;
Increased in acute viral hepatitis

32

Lewy bodies:

Abnormal aggregates of protein that develop inside nerve cells in Parkinson's Disease.

Appear as eosinophilic cytoplasmic inclusions in degenerating substantia nigra neurons.

33

Mallory bodies:

Damaged cytokeratin intermediate filaments found in cytoplasm of hepatocytes => ballooning.

Classically found in alcoholic hepatitis

34

Meckel Diverticulum:

Bulge in small intestine (blind-ended tubular protrusion), vestigial remnant of vitelline duct or yolk sac.

Most common malformation of GI tract.

35

Orphan Annie nuclei:

Nuclei that appear empty, found in Papillary adenocarcinoma of thyroid

36

Popcorn (L&H) cell:

Variant of RS cells.

Found in some types of HL.

37

Psammoma bodies:

Dystrophically calcified cancer cells, found in:
- Papillary adenocarcinoma of thyroid gland
- Prolactinoma
- Serous cystadenocarcinoma of ovary
- Meningioma
- Mesothelioma

38

Punched-out lesions:

Occur in bone in Multiple Myeloma, most common site is vertebrae

39

Reed-Sternberg (RS) cell:

Neoplastic cell of HL, most are of B-cell origin

40

Rheumatoid factor:

Predominantly IgM; Auto-antibody against IgG (Fc portion).

Typically occurs in Rheumatoid arthritis (not pathognomonic), but also SLE, Sjogren's syndrome

41

Rokitansky tubercle:

Nipple-like structure in wall of Cystic Teratoma

42

Schaumann bodies:

Laminated calcium concretions found in granulomas of Sarcoidosis

43

Schiller-Duval bodies:

Found in Yolk sac tumor, resemble primitive glomeruli.

44

Signet ring cells:

Cell with large vacuole, most frequently associated with stomach cancer.

Also found in Krukenburg tumor in ovaries (from hematogenous spread of gastric cancer)

45

Snowstorm appearance:

In ultrasound of Complete mole ( Gestational trophoblastic neoplasm)

46

Staghorn calculus:

Struvite stone, upper urinary tract stone composed of Magnesium Ammonium Phosphate (MAP), resulting from urease-producing bacterial infections (Proteus)

47

Starry Sky appearance:

Found in Burkitt lymphoma.

Neoplastic B cells, and reactive histiocytes containing phagocytic debris.

48

Virchow nodes:

L. supraclavicular lymph nodes

49

Weibel-Palade bodies:

“glue factory” of endothelial cells, synthesize P-selectin

50

Xanthelasma:

Yellow plaque on eyelid due to cholesterol deposited in macrophages (foam cells) in interstitial tissue.

Found in Primary biliary cirrhosis

51

Xanthoma:

Deposition of yellowish-cholesterol-rich material that can appear anywhere in the body.

Cutaneous Lipidosis in which lipids accumulate in large foam cells within the skin.

52

Lines of Zahn:

Alternating pale and red areas of laminated thrombi in heart chambers and aorta

53

Zenker's Diverticulum:

Outpouching of mucosa and submucosa in upper esophagus, above upper esophageal sphincter (above cricopharyngeal muscle) (= area of weakness)