Flashcards in Pathomorphology WORDS Deck (53):
Anitschkow cells (Caterpillar cells):
Reactive histiocytes (enlarged macrophages), found within granulomas associated with Rheumatic Fever.
Rheumatic fever, in myocardial tissue.
Central area of fibrinoid necrosis surrounded by Anitschkow (caterpillar) cells.
Contains lymphocytes, plasma cells, multinucleated giant cells.
Stellate inclusions found in giant cells of granulomas in diseases such as sarcoidosis
Fibrous plaque (cap) in atherosclerosis, made of SMCs, foam cells, inflammatory cells, ECM, & lipids.
Overlies a necrotic center
Fused azurophilic granules, present in Acute Myeloblastic Leukemia (AML)
Bence Jones protein:
Light chains in urine.
Tumor marker in multiple myeloma and Waldenstrom macroglobulinemia
Cysts with hemorrhage found in Fibrocystic change (FCC) of breast.
No malignant potential.
Brown tissue discoloration caused by accumulation of Lipofuscin in primary lysosomes.
Normal age-related finding in the elderly.
Found in Granulosa-theca cell tumor
Found in asthmatics, formed by crystalline granules in eosinophils
Endometrioma; Type of ovarian cyst linked to endometriosis.
Clara (club) cells:
Bronchiolar exocrine dome-shaped cells with short microvilli, found in bronchioles.
Most commonly gives rise to Bronchioloalveolar carcinoma (adenocarcinoma of lung)
Fracture of distal radius in forearm w/ dorsal & radial displacement of wrist and hand.
Often seen in osteoporosis
Virulence factor (protein) produced by TB inside phagosomes of alveolar macrophages, prevents fusion of lysosomes w/ phagosome
Apoptotic hepatocyte, found in viral hepatitis
Crystals of Reinke:
Found in Pure Leydig cell tumors
Spiral-shaped mucus plugs from subepithelial mucous gland ducts or bronchioles;
Found in sputum of asthmatics
Light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils.
Kyphosis (forward bending of spine) due to advanced osteoporosis.
Increased risk for Colles fracture of distal radius.
Black, pigmented alveolar macrophages produced by phagocytosis of black anthracotic pigment (coal dust) in Coal worker's pneumoconiosis.
Above lower esophageal sphincter
Grossly visible lesions in the development of atherosclerosis.
Irregular yellow-white discoloration of luminal surface of the artery.
Fat-containing macrophages seen in atherosclerosis, produced when body sends macrophages to location of a fatty deposit on blood vessel walls.
Caseous necrosis in periphery of lungs found in primary TB
Caseous necrosis in hilar lymph nodes in primary TB
Heart Failure cells:
Alveolar macrophages with Hemosiderin.
Gives sputum a rusty-brown color.
Inclusions within RBCs composed of denatured (damaged) hemoglobin (by oxidant damage or from inherited mutation)
Copper deposits in Descemet membrane of cornea, found in Wilson's Disease (not pathognomonic).
Also found in primary biliary cirrhosis (PBC).
Thin, linear pulmonary opacities seen on chest radiographs with interstitial pulmonary edema
Give rise to Small cell Carcinoma (SSC) of lung
Stellate macrophages located in liver, lining walls of sinusoids.
Activation => Early ethanol-induced liver injury;
Increased in acute viral hepatitis
Abnormal aggregates of protein that develop inside nerve cells in Parkinson's Disease.
Appear as eosinophilic cytoplasmic inclusions in degenerating substantia nigra neurons.
Damaged cytokeratin intermediate filaments found in cytoplasm of hepatocytes => ballooning.
Classically found in alcoholic hepatitis
Bulge in small intestine (blind-ended tubular protrusion), vestigial remnant of vitelline duct or yolk sac.
Most common malformation of GI tract.
Orphan Annie nuclei:
Nuclei that appear empty, found in Papillary adenocarcinoma of thyroid
Popcorn (L&H) cell:
Variant of RS cells.
Found in some types of HL.
Dystrophically calcified cancer cells, found in:
- Papillary adenocarcinoma of thyroid gland
- Serous cystadenocarcinoma of ovary
Occur in bone in Multiple Myeloma, most common site is vertebrae
Reed-Sternberg (RS) cell:
Neoplastic cell of HL, most are of B-cell origin
Predominantly IgM; Auto-antibody against IgG (Fc portion).
Typically occurs in Rheumatoid arthritis (not pathognomonic), but also SLE, Sjogren's syndrome
Nipple-like structure in wall of Cystic Teratoma
Laminated calcium concretions found in granulomas of Sarcoidosis
Found in Yolk sac tumor, resemble primitive glomeruli.
Signet ring cells:
Cell with large vacuole, most frequently associated with stomach cancer.
Also found in Krukenburg tumor in ovaries (from hematogenous spread of gastric cancer)
In ultrasound of Complete mole ( Gestational trophoblastic neoplasm)
Struvite stone, upper urinary tract stone composed of Magnesium Ammonium Phosphate (MAP), resulting from urease-producing bacterial infections (Proteus)
Starry Sky appearance:
Found in Burkitt lymphoma.
Neoplastic B cells, and reactive histiocytes containing phagocytic debris.
L. supraclavicular lymph nodes
“glue factory” of endothelial cells, synthesize P-selectin
Yellow plaque on eyelid due to cholesterol deposited in macrophages (foam cells) in interstitial tissue.
Found in Primary biliary cirrhosis
Deposition of yellowish-cholesterol-rich material that can appear anywhere in the body.
Cutaneous Lipidosis in which lipids accumulate in large foam cells within the skin.
Lines of Zahn:
Alternating pale and red areas of laminated thrombi in heart chambers and aorta