Pathophysiology of Coagulation Disorders Flashcards
(29 cards)
What lab tests may be run in order to assess for platelet disorders?
Platelet count, peripheral blood morphology, platelet function tests, platelet aggreggation studies
What is the function of desmopressin?
Synthetic analog of vasopressin that elevates VII & VWF levels in the blood
Tissue factor is involved in what coagulation pathway?
Extrinsic pathway
What is the MOA of warfarin?
Warfarin inhibits the Vitamin K reductase, thus preventing activation of Vitamin K-dependent clotting factors
What is the body’s first response to tissue injury?
Vasoconstriction - followed by adhesion, activation, and aggregation
What is Antiphospholipid Syndrome?
A systemic autoimmune disorder that causes the formation of abnormal clots. It is associated with thrombosis, pregnancy morbidity, and aPL antibodies
What Factor is deficient in Hemophilia C?
Factor XI
What clotting factors are Vitamin K-dependent?
II, VII, IX, X
What is the function of Protein C and Protein S?
Protein S is a cofactor of Protein C. When bound together, they act as an anti-coagulant
Von Willebrand Disease is what type of inherited platelet defect?
Adhesion defect
What is VW Disease?
An autosomal dominant quantitative deficiency or functional abnormality in vWF
True/False. The intrinsic coagulation pathway is quicker than extrinsic.
False. The extrinsic coagulation pathway occurs more quickly than intrinsic.
Fibrinogen is also known as…?
Coagulation Factor I
A clinician wants to test if a patient has a defect in the clotting cascade. What tests can they run to determine if the issue is within the cascade or not?
PT (Extrinsic Pathway)
PTT (Intrinsic Pathway)
A normal test indicated the clotting cascade is adequate and the bleeding disorder is due to another cause (ex: drug inhibitor)
Coagulation Factor III is also known as…?
Tissue Factor
Prothrombin is also known as…?
Coagulation Factor II
True/False. Warfarin is recommended for use in emergencies or with current clots.
False. Warfarin can take some time to become effective. Heparin is used for current clots and surgeries.
Where are many anti-coagulant factors synthesized?
Liver (Protein C, Protein S, anti-thrombin)
Platelet disorders related to drug use, disease, or surgical procedures are termed…?
Acquired platelet disorders
What are the four categories of inherited platelet defects?
Recruitment defects, secretion defects, cohesion defects, adhesion defects
What is the effect of a gain-of-function mutation in the prothrombin gene?
Responsible for hypercoagulability state and thus increased clotting
What is the most common acquired thrombotic disorder?
Antiphospholipid Syndrome (APS)
The body exists in a homeostatic balance between fibrinolysis and coagulation. What natural anti-coagulant prevents the continuous activation of Coagulation Factor III?
Tissue Factor Pathway Inhibitor (TFPI)
What is the mechanism of Factor V Leidan?
FVL renders Factor V insensitive to protein C, which acts as an anti-coagulant. The result is increased clotting
