Flashcards in Pathophysiology of Gastric Disease Deck (24):
What name is given to a common condition that describes a group of symptoms rather than one predominant symptom. These symptoms include:
- Belly pain or discomfort
- Feeling uncomfortably full after eating
- Loss of appetite
- Burping up food or liquid (regurgitation)
Name the 2 locations peptic ulcers are commonly found.
1. Lesser curvature
Describe what zollinger-ellison syndrome is.
Zollinger-Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of the small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes the stomach to produce too much acid.
Give some symptoms of gastro-oesophageal reflux disease (GORD).
- Sore throat
- Dysphagia (difficulty swallowing)
Give some causes of gastro-oesophageal reflux disease (GORD).
- Lower oesophageal sphincter problems
- Delayed gastric emptying (which causes raised intra gastric pressure which in turn opens the lower oesophageal sphincter)
- Hiatus hernia (When part of your stomach moves up into your chest
What problems may arise as a result of gastro-oesophageal reflux disease (GORD)?
- Strictures (as a result of inflammation and subsequent fibrosis)
- Barrett's oesophagus
How can gastro-oesophageal reflux disease (GORD) be treated?
- Lifestyle modifications i.e. diet
- Surgery i.e. to improve sphincter but wrapping fundus around
- H2 antagonists
- Proton pumps inhibitors
Give some causes of acute gastritis.
- Heavy use of NSAIDS (i.e. aspirin)
- Lots of alcohol
- Bile reflux
Why does heavy use of NSAIDS cause gastritis?
They cause an increase in prostaglandins which are required to provide sufficient blood supply to the mucus layer of the stomach.
Give some causes of chronic gastritis.
- H-pylori infection
- Autoimmue disease against gastric parietal cells
- Chronic alcohol abuse
- Chronic NSAID abuse
Name 3 complications of a H-pylori infection.
1. Peptic ulcers
3. MALT lymphoma
Name some of the normal defence mechanisms the stomach has to defend itself.
- Mucus layer
- Adequate mucosal blood flow
- Prostaglandins (stimulates above)
- Epithelial renewal
Give some symptoms of peptic ulcer disease.
- Epigastric pain
- Burning following meals
- Often pain at night in duodenum gastric ulcers)
- Weight loss
How is gastric pathology investigated?
- Chest X-ray checking for presence of gas due to perforation
- Blood test checking for anemia
What test is used to determine is H.Pylori is present?
Urease breath test
How is H.Pylori treated?
PPI+ Clarithromycin+ Amoxicillin
How is H.Pylori spread?
Oral to oral, or faecal to oral
What gram stain is H.Pylori?
How does H.Pylori cause problems within the stomach?
- Releases cytotoxins
- Expresses enzymes i.e. urease which produces ammonia which is toxic to epithelial
- Promotes inflammatory responce
How does H.Pylori affect stomach activity if it colonises the antrum?
- Increased gastrin secretion
- Increased partial cell activation
- Increased acid secretion
- This leads to epithelial metaplasia and ulceration
How does H.Pylori affect stomach activity if it colonises the antrum and the body?
How does H.Pylori affect stomach activity if it colonises the body?
Atrophic effect which results in gastric ulcers and intestinal metaplasia which could in turn lead to dysplasia and eventually cancer.