PBL Case 4 LOs

Question 1

Ezetimibe MOA

Answer 1

Prevent cholesterol absorption at small intestine brush border –> Large decrease in LDL (HDL and TGs no change)

Question 2

Statin MOA

Answer 2

Inhibt conversion of HMG CoA to mevalonate by inhibiting HMG-CoA Reductase –> Increase HDL, Decrease TGs, greatly decrease LDL

Question 3

Bile Acid resins drug names

Answer 3

Cholestyramine, colestipol, colesevelam

Question 4

Bile acid resins MOA

Answer 4

Prevent intestinal reabsorption of bile acids into the liver –> liver must use cholesterol it already has to make more ==> Large decrease in LDL, slight increase in TGs and HDL

Question 5

Fibrates drug names

Answer 5

Gemfibrozil, Clofibrate, Benzfibrate, Fenofibrate

Question 6

Fibrates MOA cholesterol

Answer 6

Upregulate lipoprotein lipase = increase TG clearance. PPAR-alpha induces HDL synthesis. –> Dec. TGs and LDL, increase HDL

Question 7

Niacin =

Answer 7

Vitamin B3

Question 8

Niacin MOA

Answer 8

Inhibits Lipolysis (hormone sensitive lipase) in adipose tissue, reduces hepatic VLDL synthesis