PCOL M2.3

Question 1

• Oxazepam

Answer 1

BENZODIAZEPINES
I. Short-acting (2-8 hours)

Question 2

• Midazolam

Answer 2

BENZODIAZEPINES
I. Short-acting (2-8 hours)

Question 3

• Triazolam

Answer 3

BENZODIAZEPINES
I. Short-acting (2-8 hours)

Question 4

• Chlordiazepoxide

Answer 4

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 5

• Diazepam

Answer 5

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 6

• Chlorazepate

Answer 6

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 7

• Flurazepam

Answer 7

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 8

• Quazepam

Answer 8

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 9

• Nordazepam

Answer 9

BENZODIAZEPINES
III. Long-acting (1-3 days)

Question 10

• Lorazepam

Answer 10

BENZODIAZEPINES
II. Intermediate-acting (10-20 hours)

Question 11

• Alprazolam

Answer 11

BENZODIAZEPINES
II. Intermediate-acting (10-20 hours)

Question 12

• Temazepam

Answer 12

BENZODIAZEPINES
II. Intermediate-acting (10-20 hours)

Question 13

• Estazolam

Answer 13

BENZODIAZEPINES
II. Intermediate-acting (10-20 hours)

Question 14

BENZODIAZEPINES
I. Short-acting (2-8 hours)

Answer 14

• Oxazepam
• Midazolam
• Triazolam

Question 15

BENZODIAZEPINES
II. Intermediate-acting (10-20 hours)

Answer 15

• Temazepam
• Lorazepam
• Alprazolam
• Estazolam

Question 16

BENZODIAZEPINES
III. Long-acting (1-3 days)

Answer 16

• Chlordiazepoxide
• Diazepam
• Flurazepam
• Chlorazepate
• Quazepam
• Nordazepam – active metabolite of Diazepam, Chlordiazepoxide, and chlorazepate

Question 17

BARBITURATES
Long-acting ( > 6 hours)

Answer 17

• Phenobarbital
• Barbital

Question 18

BARBITURATES
Intermediate-acting (3-5 hours)

Answer 18

• Amobarbital
• Butabarbital

Question 19

BARBITURATES
Short-acting (2 hrs.)

Answer 19

• Pentobarbital
• Hexobarbital
• Secobarbital

Question 20

Ultra-short-acting (30 minutes)

Answer 20

• Thiopental

Question 21

New sedative hypnotics in MISCELLANEOUS AGENTS

Answer 21

*Zaleplon and Eszopiclone *Ramelteon and Tasimelteon *Almorexant and Suvorexant

Question 22

Absorption and Distribution = extremely rapid

Answer 22

triazolam & diazepam

Question 23

A prodrug, is converted to its active form,
desmethyldiazepam (nordiazepam), by acid
hydrolysis in the stomach.

Answer 23

Clorazepate

Question 24

barbiturates absorbed rapidly into the blood following oral
administration.

Answer 24

eszopiclone, zaleplon,
zolpidem

Question 25

lipophilic character placental barrier during pregnancy detectable in breast milk and may exert depressant effects in the nursing infant

Answer 25

All sedative-hypnotics

Question 26

Metabolized by microsomal drug-metabolizing enzyme systems of the liver.

Answer 26

Biotransformation of BZDs

Question 27

Elimination half-life of more than 40 hours

Answer 27

Desmethyldiazepam

Question 28

Active metabolite of chlordiazepoxide, diazepam, prazepam, and clorazepate.

Answer 28

Desmethyldiazepam

Question 29

undergo alpha-hydroxylation

Answer 29

Alprazolam and Triazolam

Question 30

The resulting metabolites appear to exert short-lived pharmacologic effects because they are rapidly conjugated to form inactive glucuronides.

Answer 30

Alprazolam and Triazolam

Question 31

The short elimination half-life of ---------(2–3 hours) favors its use as a hypnotic rather than as a sedative drug.

Answer 31

triazolam

Question 32

With relatively short half-lives metabolized directly to inactive glucoronides less likely to cause residual effects.

Answer 32

Estazolam, Oxazepam, Lorazepam

Question 33

They are affected by inhibitors and inducers of hepatic P450 isozymes

Answer 33

Diazepam, Midazolam, Triazolam