Pcol Manor

Question 1

Cyclic Adenosine Monophophate (CAMP) is generated as a secondary messenger by the action of the enzyme Adenylyl Cyclase. The substrate for the synthesis of CAMP is

a. AMP
b. ADP
c. ATP
b. CGTP
e. DAG

Answer 1

C. ATP

Question 2

Which of the following drugs bind to receptors located at the cell membrane?
a. Thyroid hormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin D

Answer 2

D. Insulin. The rest act on either cytoplasmic or nuclear receptor

Question 3

Stimulation of Beta-adrenoceptor, a G-protein-linked receptor involves generation of a secondary messenger known as

a. IP3
b. cGPT
c. DAG
d. cAMP
e. Calcium ions

Answer 3

c. cAMP

Question 4

What is the mechanísm of action of Sildenafil, a drug popularly known as Viagra?

a. Inhibits phosphodiesterase (PDE) leading to increased cAMP
b. Inhibits PDE leading to increased cGMP
c. Stimulates adenylyl cyclase leading to increased cAMP
d. Stimulates guanylyl cyclase leading increased cGMP
e. Inhibits phosphodiesterase leading to decreased cGMP

Answer 4

B. Sildenafil inhibits phosphodiesterase V preventing destruction of cGMP

Question 5

The minimum dose that produces the maximum achievable response is known as

a. Potency
b. ED50
c. LD50
d. Ceiling dose
e. Minimum effective dose

Answer 5

D. Ceiling dose