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Neuro DND > PD/AD wurpel > Flashcards

PD/AD wurpel Flashcards

1
Q

Benzotropine MOA and anticholinergics ADR

A

M1 antagonist

constipation, dry mouth, nausea,
urinary retention, tachycardia, and blurred
vision. Hyperthermia and paralytic ileus

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2
Q

Dopa info

A

L-DOPA -precursor to dopamine. Converted to dopamine by DOPA; periphery most l-DOPA degraded

DA in periphery has GI and CV effects

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2
Q

Carbidopa and Benzserazide

A

do not cross BBB, inhibit peripheral conversion of l-DOPA to DA, allows
reduction of dose

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2
Q

What can pramipexole cause ?

A

Sleep attacks, compulsive behaviors and pathologic gambling

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2
Q

What can ropinirole cause ?

A

Hallucinations

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3
Q

Rotigotine MOA and SE

A

D2 agonist in caudate-putamen (10-fold selectivity for the D3 receptor over the D2).

Psychological SE/ADR

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4
Q

Apomorphine MOA

A

nonselective DA agonist, DA2 > DA1

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5
Q

Tolcapone

A

COMT inhibitor liver tox NO

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5
Q

Entacapone MOA

A

COMT inhibitor, does not cross BBB

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6
Q

Selegeline / Rasigaline MOA

A

MAO-B inhibitor

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7
Q

Amantadine MOA

A

NMDA antag, DA rel & blocks reuptake

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8
Q

Pimavanserin MOA

A

5-HT2A inverse agonist

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9
Q

Opicapone

A

qD HS

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9
Q

Huntingtons chorea meds and dosing

A

Tetrabenazine (Xenazine) t1/2~5-6 hr

Deutetrabenazine (Austedo) t1/2~17hr, qD dosing

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10
Q

Alzheimers meds and association

A
  • Tacrine (Cognex) - AchEI & BuChEI
  • Donepezil (Aricept) - AchEI
  • Rivastigmine - AchEI & BuChEI
  • Galantamine (Razadyne, Reminyl) - AchEI & allosteric nicotinic modulation - dual mechanism of action
  • Memantine - uncompetitive (open-channel) NMDA receptor antagonist, preventing glutamate
    action on this receptor. Memantine has a preference for the NMDA receptor-operated cation channels
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11
Q

Stroke

A

Neuroprotectants-

edaravone - free radical scavenger

cerebrolysin - counteracts excitotoxicity, reduces free radicals and inflammatory reactions & apoptosis.
REGENERATION pathways activated

12
Q

Multiple sclerosis - Fingolimod (Gilenya) MOA

A

blocks ability of lymphocyte to leave lymph node, cannot access CNS, fingolimod-
phosphate initially activates lymphocyte S1P1 (sphingosine-1 phosphate) via high-affinity receptor binding
later S1P1 down-regulation that prevents lymphocyte egress.

13
Q

Multiple sclerosis - Laquinimod MOA

A

nhibits: demyelination, microglial activation, gliosis, apoptosis of
oligodendrocytes. Decreases proinflammatory factors.

Neuro DND (3 decks)

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