Pediatric Thrombocytopenia - Newman Flashcards Preview

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Flashcards in Pediatric Thrombocytopenia - Newman Deck (13)
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1
Q

what is considered normal platelet count?

A

150-450k

2
Q

what is considered thrombocytopenia?

A

<150k

3
Q

what platelet count is spontaneous bleeding possible?

A

50k

4
Q

what platelet count is life threatening hemorrhage possible?

A

<10k

5
Q

presents after acute gastroenteritis (within 2 weeks), classic triad of:

  • microangiopathic hemolytic anemia
  • thrombocytopenia
  • acute renal damage
A

HUS

- most cases caused by E.coli shiga toxin

6
Q

what are the clinical manifestations of platelet disorders?

A
  • petechiae
  • purpura
  • gingival bleeding
  • epistaxis
  • menorrhagia
  • hematuria
7
Q

tiny subQ micro-hemorrhages which appear as scattered discrete purple/red non-blanching pinpoint macules

A

diffuse petechial rash

8
Q

purple/red spots on the skin, do not blanch on applying pressure, caused by bleeding underneath the skin, bigger than petechiae

A

purpura

9
Q

MCC isolated thrombocytopenia in otherwise well children

  • manifests as sudden onset of petechiae and bruising
  • platelet count usually <20k (those present are large)
  • PT/PTT and other cell lines normal
  • often follows VIRAL illness
A

acute idiopathic thrombocytopenic purpura

  • aka IMMUNE thrombocytopenia purpura
  • overall, 20% becomes chronic
10
Q

what is the tx of acute ITP?

A
  • prednisone
  • IVIG
  • anti-D immunoglobulin
11
Q

thrombocytopenia and hypofibrinogenemia secondary to giant hemangioma and associated intravascular coagulation

A

Kasabach-Merritt syndrome

12
Q
  • peak incidence 2-6 years
  • no sex preference
  • infection common 1-3 weeks before
  • platelets <20k
  • eosinophilia common
  • duration 2-6 weeks
  • spontaneous remission in 80% of cases
A

acute ITP

13
Q
  • peak incidence 20-40 years
  • 3:1 F:M preference
  • infection before is uncommon
  • insidious onset of bleeding
  • platelets 30-80k
  • eosinophilia rare
  • duration months-years
  • spontaneous remission uncommon
A

chronic ITP