Pemphigoid

Question 1

What drugs can cause Bullous pemphigoid?

Answer 1

GP SPACED PEN

Gliptins, Gold
PD1/Pembro, Penicillamine

Sulfa
Penicillin
ACEi
Diuretics

Psoralens
Epileptics
NSAIDs

Question 2

What are the clinical variants of Bullous Pemphigoid?

Answer 2

Question 3

What HLA classes are ass BP?

Answer 3

DRB1
DQB1

Question 4

What antigens are ass with MMP?

Answer 4

BP 180
BP 230
Laminin 332
Type VII collagen
integrin B4 and Alpha 6

Question 5

What is the prognosis of MMP?

Answer 5

Chronic
Significant morbidity
Rarely Fatal

Question 6

HIstology findings MMP?

Answer 6

Subepidermal blister (Lamina lucida)

A mixed cellular infiltrate:
- Neutrophils
- Eosinophils (fewer than BP)
- Plasma cells (oral lesions)

Question 7

DIF findings in MMP?

Answer 7

Fine linear deposits of IgG, IgA, and/or C3 along the epithelial BMZ in perilesional biopsy specimens

Question 8

What substrate do you use for IIF for MMP?

Answer 8

Human skin or oral / genital mucosa

Question 9

Systemic Rx for MMP?

Answer 9

FIrst Line - Dapsone (50 - 150mg)

Second Line
Oral Pred
Aza
MMF
Ciclosporin
MTx
IVIG
Ritux

Adjuncts: nicotinamide, doxycylcine

Question 10

Complicaitons of MMP?

Answer 10

Scaring
Dyspigmentation
Blindness
Strictures

Infection
Malignancy - SCC

Question 11

What is the significance of laminin 332 in MMP?

Answer 11

Ass with malignancy

Question 12

Rx for BP

Answer 12

Question 13

Ass. with EBA

Answer 13

Crohns
UCs
Myeloma
RA
Thyroiditis
DM