Penicillin Flashcards
How does penicillin interfere with bacterial cell wall synthesis?
It interferes with the transpeptidation or cross-linkage essential for cell wall integrity, causing cell lysis
Penicillin G’s spectrum and resistance to penicillinase, method of administration
Narrow spectrum, gram +, isn’t resistant, parenteral
True or False Penicillin G holds up well in the stomach
False
Pincillin V spectrum, route of administration resistant to pinicillinase?
Narrow spectrum, gram +, oral, no
More stable in acidic environment due to R group
Oxacillin spectrum, route, resistance to penicillinase?
Narrow spectrum, gram +, oral, yes
Amoxicillin spectrum, route of administration, resistant to penicillinase?
extended spectrum, hits additional gram -, oral, well absorbed
Where does the term MRSA come from?
Methicillin is a toxic prototype drug formin the group in which oxacillin comes from.
Is oral pen v or oral pen G better absorbed?
Pen V is better absorbed and thus reaches a higher peak in the plasma level.
Depot Benzathine Pen G is very useful due to its’ slow leak into the PM as a treatment for
The early stages of Syphilis
What class does the hospital drug imipenem fall into?
Carbapenem
What kind of spectrum does imipenem have?
Very broad spectrum, parenteral
True/False Clavulanic Acid is an antibiotic? What does it do?
False. It blocks penicillinase.
How is clavulanic acid administered?
Oral or parenteral with a penicilin (Augmentin)
Which drug has a narrow spectrum (gram +) and is resistant to penicillinase and is used for very specific, multi-microbial cases?
Vancomycin
What is the name of a drug that is toxic internally but is used as an OTC ointment.
Bacitracin
