Penicillins

Question 1

Beta Lactam allergy effects what drug classes

Answer 1

PCN and cephalosporins

Question 2

What is an example of Penicillinase Resistant PCN

Answer 2

Nafcillin

Question 3

Nafcillin MOA, clinical application, avoidance, and SE

Answer 3

MOA: inhibits cell wall, bacteriocidal
USE: Gram Positives: MSSA, CONs, COPs
Avoid: enterococci or MRSA
SE: Acute interstitial nephritis, phlebitis, bone marrow suppression

Question 4

Aminopenicillin (Ampicillin) MOA and use

Answer 4

MOA: Bacteriocidal, inhibits cell wall
USE: some gram negative coverage , Strep and Enterococcus, CNS coverage, clostridia, listeria, N. Meningitis

Question 5

Aminopenicillin (Ampicillin) avoid use and side effects

Answer 5

Avoid use in staph
SE: Rash not a true allergy

Question 6

Ampicillin/sulbactam MOA and clinical applications

Answer 6

MOA: Bactericidal, inhibits cells wall and beta lactamase
USE: Gram pos, gram neg, and anaerobes, H. Influenza

Question 7

Ampicillin/sulbactam avoid use and SE

Answer 7

Avoid use in strep
SE: Eosinophilia, phlebitis, fever, rash

Question 8

Antipseudomonal penicillin (Piperacillin/Tazobactam) MOA and use

Answer 8

MOA: Bactericidal,, inhibits cell wall, and beta lactamase
USE: Gram pos, gram neg, anaerobes, MDRO

Question 9

Piperacillin/Tazobactam avoid use and SE

Answer 9

Avoid use in ESBL
SE: AKI if given with vanco, impaired platelet aggregation, and bone marrow suppression