Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antibiotics > Penicillins > Flashcards

Penicillins Flashcards

1
Q

What is the MOA of Penicillins?

A

Beta lactam ring will inhibit the last step of bacteria’s cell wall synthesis & will also destroy existing cell wall by bacterial autolysins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Bacteria must have _________ to be susceptible to PCNs.

A

Peptidoglycan cell walls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

PCNs and ________ have synergistic effects when used to together.

A

Aminglycosides (PCNs break down cell wall for easy entry of ahminoglycosides)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PCNs are the drug that’s most commonly associated with what adverse reaction?

A

Hypersensitivity (from rash to anaphylaxis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What adverse reaction to the kidneys can PCNs have?

A

Acute interstitial nephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are hematologic adverse effects PCNs can have?

A

Neutropenia & thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are 2 other adverse effects PCNs can have?

A

Seizures at higher doses and diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the natural PCNs made from?

A

Mold

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are indications for the natural PCNs?

A

Group A & B strep infections, dental infections, Syphilis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the PCNs indicated for staphylococcal skin/soft tissue infections?

A

Anti-staph PCNs are Oxacillin, Dicloxacillin, Nafcillin, Methicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The anti-staph PCNs are not active against what?

A

MRSA, enterococcus, or gram negatives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 2 aminopenicillins?

A

Amoxicillin & Ampicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Aminopenicillins are known to be active against what 2 specific kinds of infections?

A

Enterococcus & listeria monocytogenes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Amoxicillin is the drug of choice for what 2 conditions?

A

Infectious endocarditis prophylaxis & acute otitis media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 2 names of AminoPCNs combined with beta-lactamas inhibitors?

A

Augmentin & Unasyn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is Augmentin made of?

A

Amoxicillin + Clavulanate

17
Q

What is Unasyn made of?

A

Ampicillin + Sulbactam

18
Q

What are the 3 main areas of coverage for Augmentin & Unasyn?

A

Gram +, B-lactamase gram -, Anaerobes

19
Q

What are some indications of Augmentin?

A

AOM, sinusitis, Chronic bronchitis caused by bacteria, Dental infections, Bite wounds

20
Q

What are some indications of Unasyn?

A

Skin/soft tissue infections, peritonitis

21
Q

What are 2 Antipseudomonal Penicillins?

A

Zoysn IV and Timentin IV

22
Q

What is Zosyn made of?

A

Piperacaillin + Tazobactam

23
Q

Why is Zosyvn reserved for severe infections or pseudomonas?

A

It’s the broadest spectrum PCNs

Antibiotics (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions