Peptic Ulcer Disease Flashcards

1
Q

What level does the pyloric sphincter sit at?

A

L1

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2
Q

What structure does the greater omentum adhere to?

A

the transverse colon

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3
Q

what nerve supplies the pyloric sphincter region?

A

the nerve of latarjet - which is a branch of the Vagus nerve

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4
Q

posterior ulcers in the first part of the duodenum risk eroding which artery?

A

the gastroduodenal artery

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5
Q

what structure marks the end of the embryonic foregut?

A

the duodenal papilla

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6
Q

At what level is the 2nd part of the duodenum?

A

L2/3

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7
Q

Ulcers in what structure may erode the abdominal aorta?

A

in the 2nd part of the duodenum

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8
Q

where does the duodenum become the jejunum?

A

at the duodenojejunal flexure/junction (about level L1)

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9
Q

what ligament anchors the duodenal jejunal flexure to the diaphragm?

A

Ligament of Treitz

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10
Q

what are the four anatomical regions of the stomach?

A

cardia, fundus, corpus and antrum

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11
Q

describe the surfaces of the stomach

A

the surface of the stomach exhibits coarse rugae - infoldings of mucosa and submucosa

microscopically the mucosa is punctuated by gastric pits (glands)

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12
Q

what cells live in which region of the stomach?

ex answer) the … cells live in the corpus of the stomach

A

Cardia = loosely packed mucous secreting glands

Corpus/Fundus = parietal cells (acid/intrinsic factor/histamine producing)

Antrum = mucous secreting glands and G cells (produce gastrin, serotonin, somatostatin)

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13
Q

by what mechanisms does the stomach protect itself from erosion?

A

through

1) mucous secretion
2) bicarbonate secretion
3) epithelial barrier
4) Mucosal Blood Flow (provides bicarb, O2, nutrients)

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14
Q

where in the stomach do the strongest peristaltic contractions occur?

A

in the antrum

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15
Q

Increased gastric emptying occurs as a result of what?

A
  • mechanical distension
  • increased parasympathetic activity
  • action of gastrin (produced by G cells)
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16
Q

What factors slow gastric emptying?

A

slowed by acid or fat in duodenum

expediting pH neutralisation and intestinal lipid absorption

17
Q

what are the risk factors for Peptic Ulcer Disease?

A
  • smoking
  • alcohol
  • stress
  • NSAIDs
  • Corticosteroids
18
Q

what is the most common cause of peptic ulcers?

A

Helicobactor Pylori infection

19
Q

how do we detect H. Pylori?

A
  • circulating antibodies
  • urea production in breath test
    *
20
Q

what are the symptoms of peptic ulcers?

A

aching/burning epigastric pain

pain that tends to appear soon after eating

back pain

symptoms of anaemia

21
Q

what are the signs of peptic ulcer disease?

A

epigastric tenderness

(if perforated gaurding, rebound, and rigidity either localized or generalised)

signs of anaemia

haematemesis

melaena

22
Q

what investigations do we perform for gastric ulcers?

A

gastrin levels

radiographic studies

endoscopy

23
Q

what treatment do we offer for peptic ulcers?

A

If H.Pylori positive = Triple Therapy

  • Clarithromycin
  • Amoxicillin
  • PPI
24
Q

why might a peptic ulcer fail to heal after treatmetn?

A
  • non-compliance
  • NSAID abuse
  • Crohn’s Disease
  • Gastrin Secreting tumour
  • Malignancy